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Literature summary for 3.4.24.71 extracted from

  • Palmer, J.C.; Kehoe, P.G.; Love, S.
    Endothelin-converting enzyme-1 in Alzheimers disease and vascular dementia (2010), Neuropathol. Appl. Neurobiol., 36, 487-497.
    View publication on PubMed
Search for more literature for 3.4.24.71

Protein Variants

Protein Variants Comment Organism
additional information overexpression of ECE-1a or 1b in CHO cells results in a 75-90% reduction in Abeta1-40 and a 45-60% reduction in Abeta1-42, completely abolished by treatment with phosphoramidon Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by thiorphan and captopril Homo sapiens
PD069185 a more selective ECE inhibitor Homo sapiens
phosphoramidon a metalloproteinase inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane ECEs are type II integral membrane-bound proteases Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ ECE-1 is a zinc metallopeptidase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid beta peptide + H2O Homo sapiens
-
 ?
-
 ?
big endothelin + H2O Homo sapiens
-
 endothelin 1 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 4 variants of isozyme ECE-1, ECE-1a, 1b, 1c and 1d
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte lower expression of ECE-1 Homo sapiens
-
brain expression analysis of ECE-1 in the temporal cortex of patients with Alzheimer's disease, vascular dementia, and controls, overview. ECE-1 occurs in vascular endothelial cells. ECE-1 mRNA or protein levels, of either full-length ECE-1 or soluble spliced variant, ECE-1sv, in Alzheimer's disease or vascular dementia show no differences compared to controls Homo sapiens
-
cerebellar Purkinje cell cerebellar, lower expression of ECE-1 Homo sapiens
-
endothelial cell ECE-1 Homo sapiens
-
H4 neuroglioma cell
-
 Homo sapiens
-
additional information ECE-1 immunohistochemic analysis, overview Homo sapiens
-
neuron ECE-1 occurs in neurons in the cerebral cortex, hippocampus, amygdala, basal forebrain nuclei, diencephalon, brain stem and cerebellar hemisphere Homo sapiens
-
neuron ECE-2 Homo sapiens
-
pyramidal neuron lower expression of ECE-1 Homo sapiens
-
umbilical vein endothelial cell i.e. HUVECs, high levels of endogenous ECE Homo sapiens
-
vascular endothelial cell ECE-1 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta peptide + H2O
-
 Homo sapiens ?
-
 ?
big endothelin + H2O
-
 Homo sapiens endothelin 1 + ?
-
 ?
big endothelin + H2O ECE-1a, 1b, 1c and 1d are all equally active on endothelin Homo sapiens endothelin 1 + ?
-
 ?
bradykinin + H2O
-
 Homo sapiens ?
-
 ?
insulin B chain + H2O
-
 Homo sapiens ?
-
 ?
additional information ECEs can hydrolyze several other biologically active peptides in vitro by cleavage on the amino side of hydrophobic residues Homo sapiens ?
-
 ?
neurotensin + H2O
-
 Homo sapiens ?
-
 ?
Substance P + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ECE-1
-
 Homo sapiens
endothelin-converting enzyme-1
-
 Homo sapiens
More endothelin-converting enzymes are a class of type II integral membrane-bound proteases, belonging to the M13 family of zinc metallopeptidases Homo sapiens