BRENDA - Enzyme Database show
show all sequences of 3.4.24.71

Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling

Cottrell, G.S.; Padilla, B.E.; Amadesi, S.; Poole, D.P.; Murphy, J.E.; Hardt, M.; Roosterman, D.; Steinhoff, M.; Bunnett, N.W.; J. Biol. Chem. 284, 22411-22425 (2009)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
GFP-tagged ECE-1 overexpression in HEK-293 cells
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
additional information
ECE-1 overexpression attenuates ERK2 activation
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
ECE-1 inhibition causes endosomal retention of the substance P neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus. ECE-1 inhibition also enhances substance P-induced expression and phosphorylation of the nuclear death receptor Nur77, resulting in cell death
Homo sapiens
additional information
ECE-1 inhibition causes endosomal retention of the substance P neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus. ECE-1 inhibition also enhances substance P-induced expression and phosphorylation of the nuclear death receptor Nur77, resulting in cell death
Rattus norvegicus
SM-19712
a specific ECE-1 inhibitor. SM-191712 causes sustained ERK2 activation in cytosolic and nuclear fractions after substance P removal
Homo sapiens
SM-19712
a specific ECE-1 inhibitor. SM-191712 causes sustained ERK2 activation in cytosolic and nuclear fractions after substance P removal
Mus musculus
SM-19712
a specific ECE-1 inhibitor. SM-191712 causes sustained ERK2 activation in cytosolic and nuclear fractions after substance P removal
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
cytosol
-
Mus musculus
5829
-
cytosol
-
Rattus norvegicus
5829
-
endosome
-
Rattus norvegicus
5768
-
endosome
-
Homo sapiens
5768
-
endosome
-
Mus musculus
5768
-
nucleus
-
Homo sapiens
5634
-
nucleus
-
Mus musculus
5634
-
nucleus
-
Rattus norvegicus
5634
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Zn2+
dependent on
Homo sapiens
Zn2+
dependent on
Mus musculus
Zn2+
dependent on
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
big endothelin + H2O
Mus musculus
-
endothelin-1 + ?
-
-
?
big endothelin + H2O
Homo sapiens
-
endothelin-1 + ?
-
-
?
big endothelin + H2O
Rattus norvegicus
-
endothelin-1 + ?
-
-
?
additional information
Homo sapiens
ECE-1 and endosomal acidification regulate the duration of substance P-induced ERK2 activation
?
-
-
-
additional information
Mus musculus
endothelin-converting enzyme-1 degrades substance P in early endosomes of epithelial cells and neurons to destabilize the endosomal mitogen-activated protein kinase signalosome and terminate signaling
?
-
-
-
additional information
Rattus norvegicus
endothelin-converting enzyme-1 degrades substance P in early endosomes of epithelial cells and neurons to destabilize the endosomal mitogen-activated protein kinase signalosome and terminate signaling
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
-
male C57Bl6 mice
-
Rattus norvegicus
-
male sprague-dawley rats
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
big endothelin + H2O
-
709039
Mus musculus
endothelin-1 + ?
-
-
-
?
big endothelin + H2O
-
709039
Homo sapiens
endothelin-1 + ?
-
-
-
?
big endothelin + H2O
-
709039
Rattus norvegicus
endothelin-1 + ?
-
-
-
?
additional information
ECE-1 and endosomal acidification regulate the duration of substance P-induced ERK2 activation
709039
Homo sapiens
?
-
-
-
-
additional information
endothelin-converting enzyme-1 degrades substance P in early endosomes of epithelial cells and neurons to destabilize the endosomal mitogen-activated protein kinase signalosome and terminate signaling
709039
Mus musculus
?
-
-
-
-
additional information
endothelin-converting enzyme-1 degrades substance P in early endosomes of epithelial cells and neurons to destabilize the endosomal mitogen-activated protein kinase signalosome and terminate signaling
709039
Rattus norvegicus
?
-
-
-
-
Cloned(Commentary) (protein specific)
Commentary
Organism
GFP-tagged ECE-1 overexpression in HEK-293 cells
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
ECE-1 overexpression attenuates ERK2 activation
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
ECE-1 inhibition causes endosomal retention of the substance P neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus. ECE-1 inhibition also enhances substance P-induced expression and phosphorylation of the nuclear death receptor Nur77, resulting in cell death
Homo sapiens
additional information
ECE-1 inhibition causes endosomal retention of the substance P neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus. ECE-1 inhibition also enhances substance P-induced expression and phosphorylation of the nuclear death receptor Nur77, resulting in cell death
Rattus norvegicus
SM-19712
a specific ECE-1 inhibitor. SM-191712 causes sustained ERK2 activation in cytosolic and nuclear fractions after substance P removal
Homo sapiens
SM-19712
a specific ECE-1 inhibitor. SM-191712 causes sustained ERK2 activation in cytosolic and nuclear fractions after substance P removal
Mus musculus
SM-19712
a specific ECE-1 inhibitor. SM-191712 causes sustained ERK2 activation in cytosolic and nuclear fractions after substance P removal
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
cytosol
-
Mus musculus
5829
-
cytosol
-
Rattus norvegicus
5829
-
endosome
-
Homo sapiens
5768
-
endosome
-
Mus musculus
5768
-
endosome
-
Rattus norvegicus
5768
-
nucleus
-
Homo sapiens
5634
-
nucleus
-
Mus musculus
5634
-
nucleus
-
Rattus norvegicus
5634
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Zn2+
dependent on
Homo sapiens
Zn2+
dependent on
Mus musculus
Zn2+
dependent on
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
big endothelin + H2O
Mus musculus
-
endothelin-1 + ?
-
-
?
big endothelin + H2O
Homo sapiens
-
endothelin-1 + ?
-
-
?
big endothelin + H2O
Rattus norvegicus
-
endothelin-1 + ?
-
-
?
additional information
Homo sapiens
ECE-1 and endosomal acidification regulate the duration of substance P-induced ERK2 activation
?
-
-
-
additional information
Mus musculus
endothelin-converting enzyme-1 degrades substance P in early endosomes of epithelial cells and neurons to destabilize the endosomal mitogen-activated protein kinase signalosome and terminate signaling
?
-
-
-
additional information
Rattus norvegicus
endothelin-converting enzyme-1 degrades substance P in early endosomes of epithelial cells and neurons to destabilize the endosomal mitogen-activated protein kinase signalosome and terminate signaling
?
-
-
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
big endothelin + H2O
-
709039
Mus musculus
endothelin-1 + ?
-
-
-
?
big endothelin + H2O
-
709039
Homo sapiens
endothelin-1 + ?
-
-
-
?
big endothelin + H2O
-
709039
Rattus norvegicus
endothelin-1 + ?
-
-
-
?
additional information
ECE-1 and endosomal acidification regulate the duration of substance P-induced ERK2 activation
709039
Homo sapiens
?
-
-
-
-
additional information
endothelin-converting enzyme-1 degrades substance P in early endosomes of epithelial cells and neurons to destabilize the endosomal mitogen-activated protein kinase signalosome and terminate signaling
709039
Mus musculus
?
-
-
-
-
additional information
endothelin-converting enzyme-1 degrades substance P in early endosomes of epithelial cells and neurons to destabilize the endosomal mitogen-activated protein kinase signalosome and terminate signaling
709039
Rattus norvegicus
?
-
-
-
-
General Information
General Information
Commentary
Organism
malfunction
ECE-1 inhibition causes endosomal retention of the substance P neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus, whereas ECE-1 overexpression attenuates ERK2 activation. ECE-1 inhibition also enhances substance P-induced expression and phosphorylation of the nuclear death receptor Nur77, resulting in cell death
Homo sapiens
malfunction
ECE-1 inhibition causes endosomal retention of the substance P neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus. ECE-1 inhibition also enhances substance P-induced expression and phosphorylation of the nuclear death receptor Nur77, resulting in cell death
Rattus norvegicus
metabolism
regulation of neuropeptide signaling at the cell surface involving ECE-1, detailed overview
Homo sapiens
metabolism
regulation of neuropeptide signaling at the cell surface involving ECE-1, detailed overview
Mus musculus
metabolism
regulation of neuropeptide signaling at the cell surface involving ECE-1, detailed overview
Rattus norvegicus
physiological function
ECE-1 regulates the duration and subcellular location of substance P-induced, beta-arrestin-dependent ERK activation, overview
Homo sapiens
physiological function
ECE-1 regulates the duration and subcellular location of substance P-induced, beta-arrestin-dependent ERK activation, overview
Mus musculus
physiological function
ECE-1 regulates the duration and subcellular location of substance P-induced, beta-arrestin-dependent ERK activation, overview
Rattus norvegicus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
ECE-1 inhibition causes endosomal retention of the substance P neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus, whereas ECE-1 overexpression attenuates ERK2 activation. ECE-1 inhibition also enhances substance P-induced expression and phosphorylation of the nuclear death receptor Nur77, resulting in cell death
Homo sapiens
malfunction
ECE-1 inhibition causes endosomal retention of the substance P neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus. ECE-1 inhibition also enhances substance P-induced expression and phosphorylation of the nuclear death receptor Nur77, resulting in cell death
Rattus norvegicus
metabolism
regulation of neuropeptide signaling at the cell surface involving ECE-1, detailed overview
Homo sapiens
metabolism
regulation of neuropeptide signaling at the cell surface involving ECE-1, detailed overview
Mus musculus
metabolism
regulation of neuropeptide signaling at the cell surface involving ECE-1, detailed overview
Rattus norvegicus
physiological function
ECE-1 regulates the duration and subcellular location of substance P-induced, beta-arrestin-dependent ERK activation, overview
Homo sapiens
physiological function
ECE-1 regulates the duration and subcellular location of substance P-induced, beta-arrestin-dependent ERK activation, overview
Mus musculus
physiological function
ECE-1 regulates the duration and subcellular location of substance P-induced, beta-arrestin-dependent ERK activation, overview
Rattus norvegicus
Other publictions for EC 3.4.24.71
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733074
Sonawane
Structural analysis of membran ...
Homo sapiens
Amino Acids
47
543-559
2015
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734428
Park
Substance P stimulates endothe ...
Homo sapiens
J. Invest. Dermatol.
135
551-559
2015
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1
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1
1
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734268
Jensen
Endothelin-converting enzyme 1 ...
Homo sapiens
J. Biol. Chem.
289
20283-20294
2014
-
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1
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1
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2
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1
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2
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3
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1
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3
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1
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1
1
-
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734370
Kido-Nakahara
Neural peptidase endothelin-co ...
Homo sapiens, Mus musculus
J. Clin. Invest.
124
2683-2695
2014
-
-
-
-
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2
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4
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2
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6
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3
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2
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2
2
-
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734684
Kuruppu
Soluble and catalytically acti ...
Homo sapiens
Mol. Cell. Proteomics
13
1091-1094
2014
-
-
-
-
-
-
1
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1
1
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2
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2
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1
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1
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2
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2
1
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735130
Whyteside
Endothelin-converting enzyme-1 ...
Homo sapiens
PLoS ONE
9
e83260
2014
-
-
-
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1
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1
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4
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4
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1
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2
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2
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734021
Pacheco-Quinto
Endothelin-converting enzymes ...
Homo sapiens
J. Alzheimers Dis.
33
S101
2013
-
-
-
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1
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5
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7
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1
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1
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7
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1
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5
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7
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1
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7
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734617
Tanneeru
-
Ligand-based drug design for h ...
Homo sapiens
Med. Chem. Res.
22
4401-4409
2013
-
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38
-
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1
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1
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38
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720472
Hasdemir
Endothelin-Converting Enzyme-1 ...
Homo sapiens
Mol. Endocrinol.
26
681-695
2012
-
-
-
-
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1
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1
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2
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1
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2
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1
1
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-
733056
Khamaisi
Hyperinsulinemia increases pla ...
Rattus norvegicus
Am. J. Hypertens.
25
109-114
2012
-
-
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5
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1
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1
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718716
Raoch
Nitric oxide decreases the exp ...
Bos taurus
Arterioscler. Thromb. Vasc. Biol.
31
2577-2585
2011
-
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1
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1
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720315
Pelayo
Endothelin-converting enzyme-1 ...
Mus musculus
J. Physiol.
589
5213-5230
2011
-
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2
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3
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2
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1
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1
1
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709470
Jullien
Phosphinic tripeptides as dual ...
Homo sapiens
J. Med. Chem.
53
208-220
2010
-
1
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17
1
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2
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1
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1
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16
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1
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17
16
1
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1
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1
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710094
Palmer
Endothelin-converting enzyme-1 ...
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8
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719207
Whyteside
ECE-1 influences prostate canc ...
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2010
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2
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720290
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Expression and functional prof ...
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1
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697033
Keeble
Re-sensitization of neuropepti ...
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1
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4
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697034
Cattaruzza
Endothelin-converting enzyme 1 ...
Homo sapiens, Rattus norvegicus
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4
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697686
Peltonen
Increase in tissue endothelin- ...
Homo sapiens
Eur. Heart J.
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2009
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2
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698259
Lee
Effects of the endothelin-conv ...
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Inflamm. Bowel Dis.
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2009
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1
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2
1
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699415
Martinez-Miguel
Endothelin-converting enzyme-1 ...
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J. Lipid Res.
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364-375
2009
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1
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1
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6
-
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699564
Schulz
Structure of human endothelin- ...
Homo sapiens
J. Mol. Biol.
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2009
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1
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1
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1
1
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1
-
1
1
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-
1
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1
1
1
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1
1
1
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-
-
1
1
-
-
-
-
-
-
-
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709039
Cottrell
Endosomal endothelin-convertin ...
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2009
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6
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1
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1
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5
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9
3
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6
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-
6
-
-
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-
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8
8
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709856
Jin
C-338A polymorphism of the end ...
Homo sapiens
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128-131
2009
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1
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-
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1
1
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683416
Roosterman
Endothelin-converting enzyme-1 ...
Homo sapiens
Endocrinology
149
2200-2207
2008
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2
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2
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1
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1
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2
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1
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1
-
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2
-
1
-
-
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1
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683702
Suekane
Enhanced expressions of endoth ...
Homo sapiens
J. Clin. Biochem. Nutr.
42
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1
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2
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1
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-
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-
-
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683837
Khamaisi
Diabetes and radiocontrast med ...
Rattus norvegicus
Kidney Int.
74
91-100
2008
1
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1
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1
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1
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1
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1
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1
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695457
Khimji
Divergent transforming growth ...
Rattus norvegicus
Am. J. Pathol.
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2008
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1
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1
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1
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1
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-
1
-
-
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-
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-
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697100
Rayhman
Small interfering RNA molecule ...
Homo sapiens
Cancer Res.
68
9265-9273
2008
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1
1
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1
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2
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2
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1
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1
1
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1
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1
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2
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1
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701191
Cerdeira
Endothelin-converting enzyme i ...
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Rev. Port. Cardiol.
27
385-408
2008
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5
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1
2
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16
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5
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683318
Raoch
The peptidase inhibitor CGS-26 ...
Bos taurus
Br. J. Pharmacol.
152
313-322
2007
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1
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1
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1
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1
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1
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4
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1
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1
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2
1
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1
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1
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1
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683321
Smollich
On the role of endothelin-conv ...
Homo sapiens
Breast Cancer Res. Treat.
106
361-369
2007
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2
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1
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1
1
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1
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-
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3
-
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2
-
-
-
-
-
-
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-
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683474
Kuruppu
Characterisation of endothelin ...
Homo sapiens
FEBS Lett.
581
4501-4506
2007
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1
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1
1
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2
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1
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1
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-
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-
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2
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4
1
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1
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-
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1
1
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2
-
1
-
-
-
1
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-
-
-
-
-
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683513
Massai
Endothelin-1 and endothelin-co ...
Homo sapiens
Histol. Histopathol.
22
1343-1354
2007
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1
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2
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1
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-
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-
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683696
Padilla
Endothelin-converting enzyme-1 ...
Homo sapiens
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179
981-997
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1
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3
1
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4
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1
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5
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-
-
-
-
-
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683713
Hyndman
Endothelin and endothelin conv ...
Fundulus heteroclitus
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1
-
1
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1
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3
-
-
1
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-
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683720
Iwase
Distribution of endothelin-con ...
Homo sapiens
J. Histochem. Cytochem.
55
1229-1235
2007
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1
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1
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3
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1
-
-
-
-
-
-
-
-
-
-
-
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683965
Buehler
Risk of coronary artery diseas ...
Homo sapiens
Pharmacogenet. Genomics
17
77-83
2007
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1
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2
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1
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1
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2
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1
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1
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-
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2
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1
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-
-
-
-
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668981
Awano
Endothelin system in oral squa ...
Homo sapiens
Int. J. Cancer
118
1645-1652
2006
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1
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1
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1
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-
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-
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-
-
-
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669533
Gokhale
Metallopeptide-promoted inacti ...
Homo sapiens
J. Biol. Inorg. Chem.
11
937-947
2006
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1
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1
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1
4
1
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-
-
-
-
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1
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669974
Hanessian
Design and synthesis of divers ...
Homo sapiens
J. Org. Chem.
71
2760-2778
2006
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-
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-
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-
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2
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683434
Fisk
Regulation of endothelin-conve ...
Homo sapiens, Rattus norvegicus
Exp. Biol. Med.
231
1048-1053
2006
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2
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2
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2
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6
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2
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683435
Dawson
Expression and localization of ...
Homo sapiens
Exp. Biol. Med.
231
1106-1110
2006
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2
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9
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-
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