BRENDA - Enzyme Database show
show all sequences of 3.4.24.71

Endothelin-converting enzyme inhibitors: their application in cardiovascular diseases

Cerdeira, A.S.; Bras-Silva, C.; Leite-Moreira, A.F.; Rev. Port. Cardiol. 27, 385-408 (2008)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
analysis of effect of various ECE inhibitors in myocardial infarction, pulmonary hypertension, arterial hypertension. Overview is given on human studies
Homo sapiens
Cloned(Commentary)
Commentary
Organism
COS-1 cell membrane with overexpression of human ECE-1
Homo sapiens
COS-1 cell membrane with overexpression of human ECE-1
Sus scrofa
Inhibitors
Inhibitors
Commentary
Organism
Structure
CGS 26303
synthetic inhibitor, ECE-1/NEP inhibitor
Homo sapiens
CGS 26303
synthetic inhibitor, ECE-1/NEP inhibitor
Sus scrofa
CGS 26582
synthetic inhibitor, ECE/NEP/ACE inhibitor
Sus scrofa
CGS 34043
synthetic inhibitor, ECE-1/NEP inhibitor
Homo sapiens
CGS 34226
synthetic inhibitor, ECE-1/NEP inhibitor
Homo sapiens
CGS 35066
synthetic inhibitor, selective ECE-1 inhibitor
Homo sapiens
CGS 35601
synthetic inhibitor, ECE/NEP/ACE inhibitor
Homo sapiens
N-(alpha-rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp
phosphoramidon, synthetic inhibitor, ECE-1/NEP inhibitor
Sus scrofa
RO 67-7447
synthetic inhibitor, selective ECE-1 inhibitor
Rattus norvegicus
SCH 54470
synthetic inhibitor, ECE/NEP/ACE inhibitor
Cavia sp.
SLV-306
KC-12792, synthetic inhibitor, ECE-1/NEP inhibitor, clinical trial for treatment of arterial hypertension and heart failure in human
Homo sapiens
SM-19712
synthetic inhibitor, selective ECE-1 inhibitor
Sus scrofa
WS-79089B
natural inhibitor, selective ECE-1 inhibitor
Bos taurus
WS75624A
natural inhibitor, selective ECE-1 inhibitor
Bos taurus
WS79089A
natural inhibitor, selective ECE-1 inhibitor
Bos taurus
WS79089C
natural inhibitor, selective ECE-1 inhibitor
Bos taurus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Zn2+
-
Cavia sp.
Zn2+
-
Homo sapiens
Zn2+
-
Rattus norvegicus
Zn2+
-
Sus scrofa
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Cavia sp.
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
aortic endothelial cell
-
Sus scrofa
-
carotid artery endothelial cell
-
Bos taurus
-
kidney
-
Rattus norvegicus
-
left ventricle
-
Rattus norvegicus
-
pleura
-
Cavia sp.
-
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0000012
-
-
Rattus norvegicus
RO 67-7447
0.0000058
-
human recombinant ECE-1 overexpressed in CHO cells
Homo sapiens
CGS 34043
0.000011
-
human recombinant ECE-1 overexpressed in CHO cells
Homo sapiens
CGS 34226
0.000017
-
optimized form of inhibitor, human recombinant ECE-1 overexpressed in CHO cells
Homo sapiens
CGS 26303
0.000022
-
COS-1 cell membrane with overexpression of human ECE-1
Homo sapiens
CGS 35066
0.000042
-
in vitro result, in vivo potency is lower than expected compared to in vitro result
Sus scrofa
SM-19712
0.000055
-
-
Homo sapiens
CGS 35601
0.00008
-
-
Cavia sp.
SCH 54470
0.00014
-
-
Bos taurus
WS-79089B
0.00062
-
-
Sus scrofa
CGS 26582
0.00073
-
-
Bos taurus
WS79089A
0.0011
-
long-active in vivo
Sus scrofa
CGS 26303
0.00342
-
-
Bos taurus
WS79089C
0.0035
-
potency varies with pH of medium
Sus scrofa
N-(alpha-rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp
Application (protein specific)
Application
Commentary
Organism
medicine
analysis of effect of various ECE inhibitors in myocardial infarction, pulmonary hypertension, arterial hypertension. Overview is given on human studies
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
COS-1 cell membrane with overexpression of human ECE-1
Homo sapiens
COS-1 cell membrane with overexpression of human ECE-1
Sus scrofa
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0000012
-
-
Rattus norvegicus
RO 67-7447
0.0000058
-
human recombinant ECE-1 overexpressed in CHO cells
Homo sapiens
CGS 34043
0.000011
-
human recombinant ECE-1 overexpressed in CHO cells
Homo sapiens
CGS 34226
0.000017
-
optimized form of inhibitor, human recombinant ECE-1 overexpressed in CHO cells
Homo sapiens
CGS 26303
0.000022
-
COS-1 cell membrane with overexpression of human ECE-1
Homo sapiens
CGS 35066
0.000042
-
in vitro result, in vivo potency is lower than expected compared to in vitro result
Sus scrofa
SM-19712
0.000055
-
-
Homo sapiens
CGS 35601
0.00008
-
-
Cavia sp.
SCH 54470
0.00014
-
-
Bos taurus
WS-79089B
0.00062
-
-
Sus scrofa
CGS 26582
0.00073
-
-
Bos taurus
WS79089A
0.0011
-
long-active in vivo
Sus scrofa
CGS 26303
0.00342
-
-
Bos taurus
WS79089C
0.0035
-
potency varies with pH of medium
Sus scrofa
N-(alpha-rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
CGS 26303
synthetic inhibitor, ECE-1/NEP inhibitor
Homo sapiens
CGS 26303
synthetic inhibitor, ECE-1/NEP inhibitor
Sus scrofa
CGS 26582
synthetic inhibitor, ECE/NEP/ACE inhibitor
Sus scrofa
CGS 34043
synthetic inhibitor, ECE-1/NEP inhibitor
Homo sapiens
CGS 34226
synthetic inhibitor, ECE-1/NEP inhibitor
Homo sapiens
CGS 35066
synthetic inhibitor, selective ECE-1 inhibitor
Homo sapiens
CGS 35601
synthetic inhibitor, ECE/NEP/ACE inhibitor
Homo sapiens
N-(alpha-rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp
phosphoramidon, synthetic inhibitor, ECE-1/NEP inhibitor
Sus scrofa
RO 67-7447
synthetic inhibitor, selective ECE-1 inhibitor
Rattus norvegicus
SCH 54470
synthetic inhibitor, ECE/NEP/ACE inhibitor
Cavia sp.
SLV-306
KC-12792, synthetic inhibitor, ECE-1/NEP inhibitor, clinical trial for treatment of arterial hypertension and heart failure in human
Homo sapiens
SM-19712
synthetic inhibitor, selective ECE-1 inhibitor
Sus scrofa
WS-79089B
natural inhibitor, selective ECE-1 inhibitor
Bos taurus
WS75624A
natural inhibitor, selective ECE-1 inhibitor
Bos taurus
WS79089A
natural inhibitor, selective ECE-1 inhibitor
Bos taurus
WS79089C
natural inhibitor, selective ECE-1 inhibitor
Bos taurus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Zn2+
-
Cavia sp.
Zn2+
-
Homo sapiens
Zn2+
-
Rattus norvegicus
Zn2+
-
Sus scrofa
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
aortic endothelial cell
-
Sus scrofa
-
carotid artery endothelial cell
-
Bos taurus
-
kidney
-
Rattus norvegicus
-
left ventricle
-
Rattus norvegicus
-
pleura
-
Cavia sp.
-
Other publictions for EC 3.4.24.71
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733074
Sonawane
Structural analysis of membran ...
Homo sapiens
Amino Acids
47
543-559
2015
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734428
Park
Substance P stimulates endothe ...
Homo sapiens
J. Invest. Dermatol.
135
551-559
2015
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1
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1
1
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734268
Jensen
Endothelin-converting enzyme 1 ...
Homo sapiens
J. Biol. Chem.
289
20283-20294
2014
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1
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1
1
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734370
Kido-Nakahara
Neural peptidase endothelin-co ...
Homo sapiens, Mus musculus
J. Clin. Invest.
124
2683-2695
2014
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2
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6
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2
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734684
Kuruppu
Soluble and catalytically acti ...
Homo sapiens
Mol. Cell. Proteomics
13
1091-1094
2014
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1
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1
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735130
Whyteside
Endothelin-converting enzyme-1 ...
Homo sapiens
PLoS ONE
9
e83260
2014
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2
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2
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734021
Pacheco-Quinto
Endothelin-converting enzymes ...
Homo sapiens
J. Alzheimers Dis.
33
S101
2013
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7
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1
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7
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7
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7
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734617
Tanneeru
-
Ligand-based drug design for h ...
Homo sapiens
Med. Chem. Res.
22
4401-4409
2013
-
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38
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38
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720472
Hasdemir
Endothelin-Converting Enzyme-1 ...
Homo sapiens
Mol. Endocrinol.
26
681-695
2012
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2
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1
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2
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1
1
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733056
Khamaisi
Hyperinsulinemia increases pla ...
Rattus norvegicus
Am. J. Hypertens.
25
109-114
2012
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1
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1
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718716
Raoch
Nitric oxide decreases the exp ...
Bos taurus
Arterioscler. Thromb. Vasc. Biol.
31
2577-2585
2011
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720315
Pelayo
Endothelin-converting enzyme-1 ...
Mus musculus
J. Physiol.
589
5213-5230
2011
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2
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1
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709470
Jullien
Phosphinic tripeptides as dual ...
Homo sapiens
J. Med. Chem.
53
208-220
2010
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1
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1
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710094
Palmer
Endothelin-converting enzyme-1 ...
Homo sapiens
Neuropathol. Appl. Neurobiol.
36
487-497
2010
-
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1
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3
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1
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3
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10
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10
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8
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719207
Whyteside
ECE-1 influences prostate canc ...
Homo sapiens
Can. J. Physiol. Pharmacol.
88
850-854
2010
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2
2
2
2
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720290
Wang
Expression and functional prof ...
Homo sapiens
J. Neurochem.
115
47-57
2010
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697033
Keeble
Re-sensitization of neuropepti ...
Homo sapiens
Br. J. Pharmacol.
156
728-729
2009
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1
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4
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1
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697034
Cattaruzza
Endothelin-converting enzyme 1 ...
Homo sapiens, Rattus norvegicus
Br. J. Pharmacol.
156
730-739
2009
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1
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2
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1
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2
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4
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
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697686
Peltonen
Increase in tissue endothelin- ...
Homo sapiens
Eur. Heart J.
30
242-249
2009
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1
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2
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1
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-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698259
Lee
Effects of the endothelin-conv ...
Mus musculus, Mus musculus C57BL/6
Inflamm. Bowel Dis.
15
1007-1013
2009
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1
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2
1
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1
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2
1
-
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-
-
-
-
-
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-
-
-
-
-
-
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-
699415
Martinez-Miguel
Endothelin-converting enzyme-1 ...
Bos taurus, Homo sapiens, Mus musculus, Mus musculus C57/BL6J
J. Lipid Res.
50
364-375
2009
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1
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6
-
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-
1
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1
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6
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
699564
Schulz
Structure of human endothelin- ...
Homo sapiens
J. Mol. Biol.
385
178-187
2009
-
-
1
1
1
-
1
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1
1
1
-
2
-
1
1
-
1
-
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-
1
1
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-
-
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-
-
-
-
-
-
-
-
1
-
1
1
-
-
1
-
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1
1
1
-
-
1
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709039
Cottrell
Endosomal endothelin-convertin ...
Homo sapiens, Mus musculus, Rattus norvegicus
J. Biol. Chem.
284
22411-22425
2009
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-
1
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1
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5
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9
3
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6
-
3
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-
-
-
-
-
-
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6
-
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-
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-
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1
-
-
1
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5
-
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9
3
-
6
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
8
8
-
-
-
709856
Jin
C-338A polymorphism of the end ...
Homo sapiens
Microvasc. Res.
78
128-131
2009
-
-
1
-
1
-
-
-
-
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-
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
683416
Roosterman
Endothelin-converting enzyme-1 ...
Homo sapiens
Endocrinology
149
2200-2207
2008
-
-
-
-
-
-
2
-
1
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-
-
-
3
-
-
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-
-
1
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2
-
1
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-
-
1
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-
-
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2
-
-
1
-
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-
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-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
683702
Suekane
Enhanced expressions of endoth ...
Homo sapiens
J. Clin. Biochem. Nutr.
42
126-132
2008
-
-
-
-
-
-
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1
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2
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2
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1
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1
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2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683837
Khamaisi
Diabetes and radiocontrast med ...
Rattus norvegicus
Kidney Int.
74
91-100
2008
1
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
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1
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1
-
-
-
-
-
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-
1
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-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695457
Khimji
Divergent transforming growth ...
Rattus norvegicus
Am. J. Pathol.
173
716-727
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
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-
-
-
1
-
-
1
-
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-
-
-
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-
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-
-
-
-
-
-
-
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-
1
-
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-
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697100
Rayhman
Small interfering RNA molecule ...
Homo sapiens
Cancer Res.
68
9265-9273
2008
-
1
1
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
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-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701191
Cerdeira
Endothelin-converting enzyme i ...
Bos taurus, Cavia sp., Homo sapiens, Rattus norvegicus, Sus scrofa
Rev. Port. Cardiol.
27
385-408
2008
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1
2
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16
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4
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5
-
-
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-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
14
-
1
2
-
-
-
-
14
16
-
-
-
4
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683318
Raoch
The peptidase inhibitor CGS-26 ...
Bos taurus
Br. J. Pharmacol.
152
313-322
2007
1
-
-
-
-
-
4
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-
1
-
1
-
3
-
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-
-
-
2
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
4
-
-
-
1
-
1
-
-
-
-
-
2
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
683321
Smollich
On the role of endothelin-conv ...
Homo sapiens
Breast Cancer Res. Treat.
106
361-369
2007
-
-
-
-
-
-
1
-
1
1
-
1
-
2
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
1
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683474
Kuruppu
Characterisation of endothelin ...
Homo sapiens
FEBS Lett.
581
4501-4506
2007
-
-
-
-
-
-
2
-
4
1
-
1
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2
-
-
-
-
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
4
1
-
1
-
-
-
-
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
683513
Massai
Endothelin-1 and endothelin-co ...
Homo sapiens
Histol. Histopathol.
22
1343-1354
2007
-
-
-
-
-
-
-
-
-
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-
1
-
2
-
-
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-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683696
Padilla
Endothelin-converting enzyme-1 ...
Homo sapiens
J. Cell Biol.
179
981-997
2007
-
-
1
-
1
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-
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3
1
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4
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1
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-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
3
1
-
4
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683713
Hyndman
Endothelin and endothelin conv ...
Fundulus heteroclitus
J. Exp. Biol.
210
4286-4297
2007
1
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1
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-
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-
-
3
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683720
Iwase
Distribution of endothelin-con ...
Homo sapiens
J. Histochem. Cytochem.
55
1229-1235
2007
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-
-
-
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2
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-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683965
Buehler
Risk of coronary artery diseas ...
Homo sapiens
Pharmacogenet. Genomics
17
77-83
2007
-
-
1
-
2
-
-
-
-
1
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668981
Awano
Endothelin system in oral squa ...
Homo sapiens
Int. J. Cancer
118
1645-1652
2006
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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669533
Gokhale
Metallopeptide-promoted inacti ...
Homo sapiens
J. Biol. Inorg. Chem.
11
937-947
2006
-
-
-
-
-
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4
-
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3
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
669974
Hanessian
Design and synthesis of divers ...
Homo sapiens
J. Org. Chem.
71
2760-2778
2006
-
-
-
-
-
-
2
-
-
-
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-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683434
Fisk
Regulation of endothelin-conve ...
Homo sapiens, Rattus norvegicus
Exp. Biol. Med.
231
1048-1053
2006
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-
-
-
-
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2
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2
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2
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4
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-
-
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-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
2
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683435
Dawson
Expression and localization of ...
Homo sapiens
Exp. Biol. Med.
231
1106-1110
2006
-
-
-
-
-
-
-
-
2
-
-
-
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2
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-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683437
Jafri
Phosphorylation of endothelin ...
Homo sapiens
Exp. Biol. Med.
231
713-717
2006
-
-
-
-
-
-
-
-
5
1
-
-
-
3
-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683438
Hunter
Expression and localization of ...
Homo sapiens
Exp. Biol. Med.
231
718-722
2006
-
-
-
-
-
-
-
-
2
1
-
1
-
2
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-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
1
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683439
Klipper
Identification of a novel alte ...
Homo sapiens
Exp. Biol. Med.
231
723-728
2006
-
-
1
-
-
-
-
-
2
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-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683440
Jackson
Expression and localization of ...
Homo sapiens
Exp. Biol. Med.
231
794-801
2006
-
-
-
-
-
-
-
-
1
-
-
1
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2
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-
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4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683628
Eckman
Regulation of steady-state bet ...
Mus musculus
J. Biol. Chem.
281
30471-30478
2006
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1
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2
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1
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2
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-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
4
-
-
-
-
-
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