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Literature summary for 3.4.24.71 extracted from
- PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice (2006), Proc. Natl. Acad. Sci. USA, 103, 8215-8220.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | protein kinase C epsilon, PKCepsilon, stimulates ECE-1 activity, overview | Homo sapiens | |
| additional information | protein kinase C epsilon, PKCepsilon, stimulates the amyloid-beta peptide degradation by ECE-1 in transgenic mice, overview | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of transgenic mice overexpressing human amyloid-beta peptide and protein kinase C epsilon, overview, increased ECE activity in PKCepsilon-transfected EA.hy926 cells | Mus musculus |
| additional information | increased ECE activity in PKCepsilon-transfected EA.hy926 cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | ECE-1 is a type II membrane zinc metalloprotease | Mus musculus | 16020 | - |
| membrane | ECE-1 is a type II membrane zinc metalloprotease | Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | ECE-1 is a type II membrane zinc metalloprotease | Mus musculus |  |
| Zn2+ | ECE-1 is a type II membrane zinc metalloprotease | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| big endothelin + H2O | Homo sapiens | - |
endothelin + ? | - |
? | |
| big endothelin + H2O | Mus musculus | PKCepsilon regulates the expression of ECE-1 in the brain | endothelin + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Mus musculus | - |
| brain | PKCepsilon regulates the expression of ECE-1 in the brain | Mus musculus | - |
| cerebellum | - |
Mus musculus | - |
| neuron | - |
Mus musculus | - |
| Purkinje cell | cerebellar | Mus musculus | - |
| pyramidal neuron | hippocampal and neocortical | Mus musculus | - |
| umbilical vein endothelial cell | - |
Homo sapiens | - |
| vascular endothelial cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid-beta peptide + H2O | protein kinase C epsilon, PKCepsilon, stimulates the amyloid-beta peptide degradation by ECE-1 in mice leading to a decrease in plaque-associated astrocytosis and dystrophic neurites, overview | Mus musculus | amyloid-beta peptide + ? | - |
? | |
| big endothelin + H2O | - |
Mus musculus | endothelin + ? | - |
? | |
| big endothelin + H2O | - |
Homo sapiens | endothelin + ? | - |
? | |
| big endothelin + H2O | PKCepsilon regulates the expression of ECE-1 in the brain | Mus musculus | endothelin + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ECE-1 | - |
Mus musculus |
| ECE-1 | - |
Homo sapiens |
| endothelin-converting enzyme-1 | - |
Mus musculus |
| endothelin-converting enzyme-1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
assay at | Mus musculus |
| 6.8 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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