Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.71 extracted from

  • Kuruppu, S.; Reeve, S.; Ian Smith, A.
    Characterisation of endothelin converting enzyme-1 shedding from endothelial cells (2007), FEBS Lett., 581, 4501-4506.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
phosphoramidon
-
Homo sapiens
thiorphan
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface ECE-1 shedding from the surface of endothelial cells Homo sapiens 9986
-
extracellular
-
Homo sapiens
-
-
membrane
-
Homo sapiens 16020
-
soluble
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ metalloprotease Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
big endothelin-1 + H2O Homo sapiens activation endothelin-1 + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
umbilical vein endothelial cell ECE-1 is secreted to the medium, ECE-1 shedding from the surface of endothelial cells Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxy-coumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(2,4-dinitrophenyl) + H2O fluorogenic substrate Homo sapiens ?
-
?
big endothelin-1 + H2O activation Homo sapiens endothelin-1 + ?
-
?

Synonyms

Synonyms Comment Organism
ECE-1
-
Homo sapiens
endothelin-converting enzyme-1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens