Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the peptidase inhibitor CGS-26303, bigendothelin-1, and phosphoramidon, though not thiorphan, a neutral endopeptidase inhibitor, increase endothelin converting enzyme-1 expression in endothelial cells through accumulation of big endothelin-1, CGS-26303 and big endothelin increase ECE-1 promoter activity, the stimulation is abolished by cycloheximide, overview | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CGS-26303 | specific, complete inhibition at 0.025 mM | Bos taurus | |
CGS-35066 | a selective ECE-1 inhibitor, mimicks the effects of CGS-26303 | Bos taurus | |
additional information | neither exogenously added ET-1 nor the blockade of the receptors with bosentan modifies ECE-1 protein, overview | Bos taurus | |
phosphoramidon | complete inhibition at 0.1 mM | Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
big endothelin-1 + H2O | Bos taurus | activation | endothelin-1 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Bos taurus | - |
endothelial cell | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
big endothelin-1 + H2O | activation | Bos taurus | endothelin-1 + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ECE-1 | - |
Bos taurus |
endothelin-converting enzyme-1 | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Bos taurus |