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Literature summary for 3.4.24.7 extracted from

  • Kaner, R.J.; Santiago, F.; Crystal, R.G.
    Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1(+) smokers with early emphysema (2009), J. Leukoc. Biol., 86, 913-922.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.7

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-
extracellular matrix
-
 Homo sapiens 31012
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Type I collagen + H2O Homo sapiens interstitial collagen ?
-
 ?
type II collagen + H2O Homo sapiens interstitial collagen ?
-
 ?
type III collagen + H2O Homo sapiens interstitial collagen ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification MMP-1 is activated from a pro-MMP-1 form Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelial lining fluid
-
 Homo sapiens
-
lung alveolar mucosa expression from HIV1+ smokers with early emphysema is significantly higher than in HIV1- smokers with early emphysema. Among the HIV- groups, compared with HIV1- healthy nonsmokers, smoking do not increase aqlveolar mucosa MMP-1 gene expression in HIV1- healthy smokers and HIV1- smokers with early emphysema, independent of whether emphysema is present or not. HIV1+ individuals with early emphysema have significantly increased expression of MMP-1 compared with all 3 groups of HIV1- individuals, including those with early emphysema Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Type I collagen + H2O interstitial collagen Homo sapiens ?
-
 ?
type II collagen + H2O interstitial collagen Homo sapiens ?
-
 ?
type III collagen + H2O interstitial collagen Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
macrophage matrix metalloproteinase
-
 Homo sapiens
MMP-12
-
 Homo sapiens