Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | - |
Homo sapiens | - |
keratinocyte | epidermal, primary, from foreskin | Homo sapiens | - |
skin | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
MMP-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | activation of toll-like receptors TLR2, TLR3 or TLR5 increased the expression of MMP-1. MMP-1 and MMP-9 in human epidermal keratinocytes are induced by Pam3CSK4, Poly(I:C) and flagellin, which are ligands for TLR2, TLR3 and TLR5, respectively, overview. The induction of MMP-1 by the receptor ligands is inhibited by pretreatment with BAY11-7082, a NF-kappaB inhibitor, or SP600125, a JNK inhibitor. p38 MAPK activation negatively regulates MMP-1 induction by TLR2 or TLR5 activation, but not by TLR3 activation | up |
General Information | Comment | Organism |
---|---|---|
physiological function | increased expression of MMPs by toll-like receptor activation may be involved in infection-associated inflammation, cell migration and tissue remodelling in human skin | Homo sapiens |