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Literature summary for 3.4.24.7 extracted from

  • Lee, Y.; Kim, H.; Kim, S.; Kim, K.H.; Chung, J.H.
    Activation of toll-like receptors 2, 3 or 5 induces matrix metalloproteinase-1 and -9 expression with the involvement of MAPKs and NF-kappaB in human epidermal keratinocytes (2009), Exp. Dermatol., 19, e44-e49.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
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Homo sapiens
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keratinocyte epidermal, primary, from foreskin Homo sapiens
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skin
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Homo sapiens
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Synonyms

Synonyms Comment Organism
MMP-1
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens activation of toll-like receptors TLR2, TLR3 or TLR5 increased the expression of MMP-1. MMP-1 and MMP-9 in human epidermal keratinocytes are induced by Pam3CSK4, Poly(I:C) and flagellin, which are ligands for TLR2, TLR3 and TLR5, respectively, overview. The induction of MMP-1 by the receptor ligands is inhibited by pretreatment with BAY11-7082, a NF-kappaB inhibitor, or SP600125, a JNK inhibitor. p38 MAPK activation negatively regulates MMP-1 induction by TLR2 or TLR5 activation, but not by TLR3 activation up

General Information

General Information Comment Organism
physiological function increased expression of MMPs by toll-like receptor activation may be involved in infection-associated inflammation, cell migration and tissue remodelling in human skin Homo sapiens