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Literature summary for 3.4.24.7 extracted from

  • Wilkins-Port, C.E.; Ye, Q.; Mazurkiewicz, J.E.; Higgins, P.J.
    TGF-beta1 + EGF-initiated invasive potential in transformed human keratinocytes is coupled to a plasmin/MMP-10/MMP-1-dependent collagen remodeling axis: role for PAI-1 (2009), Cancer Res., 69, 4081-4091.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.7

Activating Compound

Activating Compound Comment Organism Structure
additional information active MMP-10 does not cleave collagen type 1 directly, it does activate the collagenase MMP-1, EC 3.4.24.7. The ability of active MMP-10 to superactivate MMP-1 creates a plasmin/MMP-10/MMP-1 proteolytic axis effectively enhances collagen type 1 degradation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GM6001 a broad-spectrum MMP inhibitor Homo sapiens
PAI-1 functions as an upstream regulator of a MMP-1-initiated collagenolytic phenotype, it blocks conversion of MMP-1 to its active form. Neutralization of endogenous PAI-1 with function blocking antibodies accelerates both collagenolysis and activation of MMP-1 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens active MMP-10, EC 3.4.24.22, does not cleave collagen type 1 directly, it does activate the collagenase MMP-1 ?
-
 ?
Type I collagen + H2O Homo sapiens a plasmin/MMP-10/MMP-1 proteolytic axis effectively enhances collagen type 1 degradation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification pro-MMP1 is activated by plasmin to active MMP-1 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HaCaT II-4 cell MMP-10 and MMP-1 are up-regulated in HaCaT II-4 cells Homo sapiens
-
keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information active MMP-10, EC 3.4.24.22, does not cleave collagen type 1 directly, it does activate the collagenase MMP-1 Homo sapiens ?
-
 ?
Type I collagen + H2O
-
 Homo sapiens ?
-
 ?
Type I collagen + H2O a plasmin/MMP-10/MMP-1 proteolytic axis effectively enhances collagen type 1 degradation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
collagenase
-
 Homo sapiens
matrix metalloproteinase-1
-
 Homo sapiens
MMP-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enhanced collagen degradation, in case of epithelial-to-mesenchymal transition stimulated by transforming growth factor-beta as well as epidermal growth factor receptor, is coupled to a significant increase in matrix metalloproteinase MMP-1 expression and is involved a proteolytic axis composed of plasmin, MMP-10, ec 3.4.24.22, and MMP-1 up

General Information

General Information Comment Organism
physiological function role for MMP-1 in the TGF-beta- and EGF-stimulated collagen remodeling process Homo sapiens