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Literature summary for 3.4.24.7 extracted from

  • Goffin, L.; Seguin-Estevez, Q.; Alvarez, M.; Reith, W.; Chizzolini, C.
    Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts (2010), Arthritis Res. Ther., 12, R73.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.7

Protein Variants

Protein Variants Comment Organism
additional information disruption of the proximal AP-1-binding site in the promoter of MMP-1 severely impair MMP-1 transcription in response to bortezomib Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
TIMP-1
-
 Homo sapiens
TIMP-2
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Type I collagen + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast dermal Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Type I collagen + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens bortezomib specifically increases the steady-state mRNA levels of MMP-1 and enhances the binding of c-Jun to the promoter of MMP-1. Disruption of the proximal AP-1-binding site in the promoter of MMP-1 severely impairs MMP-1 transcription in response to bortezomib. By altering the binding of at least two transcription factors, c-Jun and SP1, proteasome inhibition results in increased production of MMP-1 and decreases synthesis of type I collagen in human dermal fibroblasts up

General Information

General Information Comment Organism
metabolism altering the binding of at least two transcription factors, c-Jun and SP1, proteasome inhibition results in increased production of MMP-1 and decreases synthesis of type I collagen in human dermal fibroblasts. Differential effects of proteasome inhibition and TGF-beta on MMP-1 and MMP-2, overview Homo sapiens
physiological function MMP-1 or interstitial collagenase unwinds native type I collagen and initiate its degradation Homo sapiens
physiological function proteasome inhibition, e.g. by inhibitor bortezomib, in vitro decreases type I collagen and enhances MMP-1 production by human fibroblasts, thus favoring an antifibrotic fibroblast phenotype. These effects are dominant over the pro-fibrotic phenotype induced by transforming growth factor-beta Homo sapiens