Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin-1 receptor antagonist | increases active MMP-1 level | Homo sapiens | |
TNF | increases active MMP-1 level | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dexamethasone | significantly decreases active MMP-1 level and inhibits active MMP-1 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dependent on | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intervertebral disc | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
basal activity in different subjects, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-1 | - |
Homo sapiens |
MMP-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | dexamethasone, and less potent also interleukin-1Ra and TNF, decrease levels of pro-MMP-1 | down |
General Information | Comment | Organism |
---|---|---|
physiological function | MMP-1 is involved in spontaneous resorption of disc herniation after sciatica, overview. MMP-3 appears to play a greater role than MMP-1 in disc herniation resorption | Homo sapiens |