Literature summary for 3.4.24.7 extracted from

Lam, K.K.; Cheng, P.Y.; Hsiao, G.; Chen, S.Y.; Shen, H.H.; Yen, M.H.; Lee, Y.M.
Estrogen deficiency-induced alterations of vascular MMP-2, MT1-MMP, and TIMP-2 in ovariectomized rats (2009), Am. J. Hypertens., 22, 27-34.

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Application

Application	Comment	Organism
medicine	in ovariectomized rats, during the first 1-4 weeks there is a significant increase in collagen accumulation and an increase MT1-MMP expression. Although active-form matrix metalloproteinase MMP-2 and collagen progressively return to normal levels, the markedly increased collagen deposition appears again at 8 weeks and persists until 12 weeks, followed by induction of MMP-2 and MT1-MMP at 12 weeks	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

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Release 2023.1 (January 2023)