Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.69 extracted from

  • Wang, D.; Krilich, J.; Pellett, S.; Baudys, J.; Tepp, W.; Barr, J.; Johnson, E.; Kalb, S.
    Comparison of the catalytic properties of the botulinum neurotoxin subtypes A1 and A5 (2013), Biochim. Biophys. Acta, 1834, 2722-2728.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.69

Activating Compound

Activating Compound Comment Organism Structure
bovine serum albumin stimulates the subtype BoNT/A hydrolysis of synthetic peptide substrates Clostridium botulinum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
 SNAP-25 at pH 7.4 and 37°C Clostridium botulinum
0.03
-
 SNAP-25 at pH 7.4 and 37°C Clostridium botulinum
0.032
-
 Ac-RGSNKPKIDAGNQRATRXLGGR-NH2 at pH 7.4 and 37°C Clostridium botulinum
0.038
-
 Ac-RGSNKPKIDAGNQRATRXLGGR-NH2 at pH 7.4 and 37°C Clostridium botulinum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 1 * 100000 + 1 * 50000, SDS-PAGE Clostridium botulinum
100000
-
 1 * 100000 + 1 * 50000, SDS-PAGE Clostridium botulinum

Organism

Organism UniProt Comment Textmining
Clostridium botulinum C7BEA8
-
-
Clostridium botulinum Q7B8V4
-
-
Clostridium botulinum A661222 C7BEA8
-
-
Clostridium botulinum Hall A hyper Q7B8V4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-RGSNKPKIDAGNQRATRXLGGR-NH2 + H2O
-
 Clostridium botulinum Ac-RGSNKPKIDAGNQR + ATRXLGGR-NH2
-
 ?
Ac-RGSNKPKIDAGNQRATRXLGGR-NH2 + H2O
-
 Clostridium botulinum Hall A hyper Ac-RGSNKPKIDAGNQR + ATRXLGGR-NH2
-
 ?
Ac-RGSNKPKIDAGNQRATRXLGGR-NH2 + H2O
-
 Clostridium botulinum A661222 Ac-RGSNKPKIDAGNQR + ATRXLGGR-NH2
-
 ?
SNAP-25 + H2O
-
 Clostridium botulinum ?
-
 ?
SNAP-25 + H2O
-
 Clostridium botulinum Hall A hyper ?
-
 ?
SNAP-25 + H2O
-
 Clostridium botulinum A661222 ?
-
 ?

Subunits

Subunits Comment Organism
heterodimer 1 * 100000 + 1 * 50000, SDS-PAGE Clostridium botulinum

Synonyms

Synonyms Comment Organism
BoNT/A1 subtype Clostridium botulinum
BoNT/A5 subtype Clostridium botulinum
Botulinum neurotoxin
-
 Clostridium botulinum