Application | Comment | Organism |
---|---|---|
medicine | clinical evidence on the effectiveness and reliability of minimally invasive and reversible sacral neuromodulation and botulinum toxin A treatment as well as the current significance of sacral neuromodulation and botulinum toxin A for the second-line treatment of adult syndrome of idiopathic overactive bladder, overview | Clostridium botulinum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium botulinum | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
Botulinum neurotoxin | - |
Clostridium botulinum |
Botulinumtoxin A | - |
Clostridium botulinum |
General Information | Comment | Organism |
---|---|---|
physiological function | the pharmacologic effect of Botulinumtoxin A includes a reversible blockade of acetylcholine, inhibition of other neurotransmitters, e.g. Substance P and ATP, and the downregulation of axonalexpression of purinergic P2X3- and capsaicin TPRV1-receptors at the nerve endings of the suburothelium, all leading to afferent desensibilization | Clostridium botulinum |