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Literature summary for 3.4.24.69 extracted from

  • Baldwin, M.R.; Barbieri, J.T.
    Association of botulinum neurotoxins with synaptic vesicle protein complexes (2009), Toxicon, 54, 570-574.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.69

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required Clostridium botulinum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Clostridium botulinum BoNT/A and BoNT/B bind a synaptic vesicle protein complex from synaptic vesicles, interactions of BoNT and host neuronal receptors, overview. Binding and entry of BoNTs at the neuromuscular junction, BoNT/A associates with the presynaptic membrane of alpha-motor neurons through interactions with oligosaccharides such as ganglioside GT1b, structure-function, modelling, overview ?
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Organism

Organism UniProt Comment Textmining
Clostridium botulinum
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Purification (Commentary)

Purification (Comment) Organism
BoNT HCR/A and HCR/B co-purify with synaptic vesicle protein complexes Clostridium botulinum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information BoNT/A and BoNT/B bind a synaptic vesicle protein complex from synaptic vesicles, interactions of BoNT and host neuronal receptors, overview. Binding and entry of BoNTs at the neuromuscular junction, BoNT/A associates with the presynaptic membrane of alpha-motor neurons through interactions with oligosaccharides such as ganglioside GT1b, structure-function, modelling, overview Clostridium botulinum ?
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Synonyms

Synonyms Comment Organism
BoNT
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 Clostridium botulinum
BoNT/A
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 Clostridium botulinum
BoNT/B
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 Clostridium botulinum
Botulinum neurotoxin
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 Clostridium botulinum

General Information

General Information Comment Organism
additional information The BoNT-receptor complex enters neurons by receptor-mediated endocytosis. Synaptic vesicle protein 2, synaptotagmin I, synaptophysin, vesicle-associated membrane protein 2, and the vacuolar ATPase-proton pump are components of the BoNT-synaptic vesicle protein complex Clostridium botulinum
physiological function botulinum neurotoxins elicit flaccid paralysis by cleaving SNARE proteins within peripheral neurons. BoNT/A and BoNT/B utilize synaptic vesicle protein 2, SV2, and synaptotagmin, respectively, as receptors for entry into neurons Clostridium botulinum