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Literature summary for 3.4.24.69 extracted from
- Extraction and inhibition of enzymatic activity of botulinum neurotoxins/A1, /A2, and /A3 by a panel of monoclonal anti-BoNT/A antibodies (2009), PLoS ONE, 4, e5355.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inhibition of enzymatic activity of botulinum neurotoxins/A1, /A2, and /A3 by a panel of monoclonal anti-BoNT/A antibodies | Clostridium botulinum |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | required | Clostridium botulinum |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridium botulinum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| extraction of enzymatic activity of botulinum neurotoxins/A1, /A2, and /A3 from Clostridium botulinum strain Loch Maree by a panel of monoclonal anti-BoNT/A antibodies, overview | Clostridium botulinum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| biotin-KGSNRTRIDQGNQRATRXLGGK-biotin + H2O | the catalytic activity resides on the light chains of the toxin molecule | Clostridium botulinum | ? | - |
? | |
| additional information | development of Endopep-MS, a mass spectrometry-based endopeptidase method for detecting and differentiating BoNT/A-G serotypes in buffer and BoNT/A, /B, /E, and /F in clinical samples | Clostridium botulinum | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BoNT/A | - |
Clostridium botulinum |
| BoNT/A1 | - |
Clostridium botulinum |
| BoNT/A2 | - |
Clostridium botulinum |
| BoNT/A3 | - |
Clostridium botulinum |
| BoNT/B | - |
Clostridium botulinum |
| BoNT/C | - |
Clostridium botulinum |
| BoNT/D | - |
Clostridium botulinum |
| BoNT/E | - |
Clostridium botulinum |
| BoNT/F | - |
Clostridium botulinum |
| BoNT/G | - |
Clostridium botulinum |
| Botulinum neurotoxin | - |
Clostridium botulinum |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Clostridium botulinum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | - |
assay at | Clostridium botulinum |
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