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Literature summary for 3.4.24.69 extracted from

  • Roxas-Duncan, V.; Enyedy, I.; Montgomery, V.A.; Eccard, V.S.; Carrington, M.A.; Lai, H.; Gul, N.; Yang, D.C.; Smith, L.A.
    Identification and biochemical characterization of small-molecule inhibitors of Clostridium botulinum neurotoxin serotype A (2009), Antimicrob. Agents Chemother., 53, 3478-3486.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
7-((4-nitroanilino)(phenyl)methyl)-8-quinolinol NSC 1010 Clostridium botulinum
CB 7969312 the quinolinol-based analogue effectively neutralizes BoNT/A toxicity, ex vivo protection at 500 nM Clostridium botulinum
additional information inhibitor virtual screening performed by computationally docking compounds of the NCI database into the active site of BoNT/A light chain, inhibition studies in neuroblastoma N2a cell-based and tissue-based mouse phrenic nerve hemidiaphragm assays, overview. Five quinolinol-based analogues effectively neutralize BoNT/A toxicity, with CB 7969312 exhibiting ex vivo protection at 500 nM Clostridium botulinum

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
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 botulinum neurotoxin serotype A, BoNT/A
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Synonyms

Synonyms Comment Organism
Clostridium botulinum neurotoxin serotype A
-
 Clostridium botulinum