Literature summary for 3.4.24.69 extracted from

McAllister, L.A.; Hixon, M.S.; Kennedy, J.P.; Dickerson, T.J.; Janda, K.D.
Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: a new wrinkle in botulinum neurotoxin (2006), J. Am. Chem. Soc., 128, 4176-4177.

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Activating Compound

Activating Compound	Comment	Organism	Structure
5-phenyl-2-acylguanidyl thiophenes	compounds containing a 2-acylthiophene moiety as a zinc-binding functionality, combined with acylguanidyl groups as an arginine side chain mimetic, structure-activity relationship of 5-phenyl-2-acylguanidyl thiophene activators of BoNT LC/A under standard screening conditions, overview	Clostridium botulinum
5-[3-(butylsulfanyl)phenyl]-N-carbamimidoylthiophene-2-carboxamide	4fold activation of BoNT LC/A	Clostridium botulinum
5-[4-(butylsulfanyl)phenyl]-N-carbamimidoylthiophene-2-carboxamide	7fold activation, BoNT LC/A activation profile, overview	Clostridium botulinum
additional information	identification of a small molecule scaffold based on 2-acyl guanidyl-5-phenyl thiophenes that strongly activates BoNT LC/A catalytic activity through an apparent reduction in KM activator screening, overview	Clostridium botulinum
N-carbamimidoyl-5-[3-(ethylsulfanyl)phenyl]thiophene-2-carboxamide	4fold activation of BoNT LC/A	Clostridium botulinum
N-carbamimidoyl-5-[3-(methylsulfanyl)phenyl]thiophene-2-carboxamide	3fold activation of BoNT LC/A	Clostridium botulinum
N-carbamimidoyl-5-[4-(ethylsulfanyl)phenyl]thiophene-2-carboxamide	3.5fold activation of BoNT LC/A	Clostridium botulinum
N-carbamimidoyl-5-[4-(propylsulfanyl)phenyl]thiophene-2-carboxamide	7fold activation of BoNT LC/A	Clostridium botulinum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
SNAP-25 + H2O	Clostridium botulinum	i.e. synaptosomal associated protein of 25 kDa	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Clostridium botulinum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SNAP-25 + H2O	i.e. synaptosomal associated protein of 25 kDa	Clostridium botulinum	?	-	?

Synonyms

Synonyms	Comment	Organism
BoNT LC/A	-	Clostridium botulinum
Botulinum neurotoxin	-	Clostridium botulinum
botulinum neurotoxin serotype A light chain	-	Clostridium botulinum

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Release 2023.1 (January 2023)