Literature summary for 3.4.24.69 extracted from

Teymoortash, A.; Sommer, F.; Mandic, R.; Schulz, S.; Bette, M.; Aumueller, G.; Werner, J.A.
Intraglandular application of botulinum toxin leads to structural and functional changes in rat acinar cells (2007), Br. J. Pharmacol., 152, 161-167.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Clostridium botulinum	intraglandular injection of botulinum toxin leads to a transient denervation of the submandibular gland and this is associated with reduced salivary secretion in Wistar rats, which may be due to glandular denervation induced by the inhibition of the soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors involved in acetylcholine release at the neuroglandular junction and also specially inhibition of those involved in exocytosis of the granula of the acinar cells. Cell organelles and secretory granula show a clear atrophy of the acini, which is more prominent in glands injected with the combination of BoNT/A and B, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Clostridium botulinum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	intraglandular injection of botulinum toxin leads to a transient denervation of the submandibular gland and this is associated with reduced salivary secretion in Wistar rats, which may be due to glandular denervation induced by the inhibition of the soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors involved in acetylcholine release at the neuroglandular junction and also specially inhibition of those involved in exocytosis of the granula of the acinar cells. Cell organelles and secretory granula show a clear atrophy of the acini, which is more prominent in glands injected with the combination of BoNT/A and B, overview	Clostridium botulinum	?	-	?

Synonyms

Synonyms	Comment	Organism
BoNT	-	Clostridium botulinum
botulinum toxin	-	Clostridium botulinum

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Release 2023.1 (January 2023)