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Literature summary for 3.4.24.69 extracted from
- Botulinal neurotoxins: revival of an old killer (2005), Curr. Opin. Pharmacol., 5, 274-279.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme is a useful therapeutic agent for many human syndroms caused by hyperactivity of cholinergic nerve terminals. Human diseases treated with BoNT/A: blepharospasm, hemifacial spasm, laryngeal dysphonia, head and neck dystonias, strabismus, limb dystonias, occupational cramps, anal fissure and rectal spasms, palmar and ascellar hyperhydrosis, hypersalivation and hypersweating, migraine headache, pain, bruxism, spasticity, urinary retention and pain, essential tremors, dysphagia and achalasia esophagea. BoNT/A is extensively used as a pharmaco-cosmetic | Clostridium botulinum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Clostridium botulinum | BoNTs are the most toxic proteins known with mouse LD50 values in the range of 1-5 ng/kg. They are responsible for the pathophysiology of botulism. BoNTs enter peripheral cholinergic nerve terminals, where they cleave one or two of the three core proteins of the neuroexocytosis apparatus and elicit persistent but reversible inhibition of neurotransmitter release | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridium botulinum | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | BoNTs are the most toxic proteins known with mouse LD50 values in the range of 1-5 ng/kg. They are responsible for the pathophysiology of botulism. BoNTs enter peripheral cholinergic nerve terminals, where they cleave one or two of the three core proteins of the neuroexocytosis apparatus and elicit persistent but reversible inhibition of neurotransmitter release | Clostridium botulinum | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BoNT | - |
Clostridium botulinum |
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Release 2023.1 (January 2023)
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