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Literature summary for 3.4.24.69 extracted from

  • Washbourne, P.; Pellizzari, R.; Baldini, G.; Wilson, M.C.; Montecucco, C.
    Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis (1997), FEBS Lett., 418, 1-5.
    View publication on PubMed

Application

Application Comment Organism
medicine BoNT/A is the best available therapeutic agent of a variety of human diseases that benefit from a finctional inhibition of cholinergic terminals Clostridium botulinum

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc endopeptidase Clostridium botulinum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Clostridium botulinum only mammalian proteins, SNAP-25 from Drosophila sp. and Torpedo sp. are no substrates ?
-
?
SNAP-25 + H2O Clostridium botulinum mammalian synaptosome associated protein ?
-
?

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
commercial preparations of BoNT/A and BoNT/E further purified Clostridium botulinum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information only mammalian proteins, SNAP-25 from Drosophila sp. and Torpedo sp. are no substrates Clostridium botulinum ?
-
?
SNAP-25 + H2O synaptosome associated protein Clostridium botulinum ?
-
?
SNAP-25 + H2O mammalian synaptosome associated protein Clostridium botulinum ?
-
?

Synonyms

Synonyms Comment Organism
BoNT/A
-
Clostridium botulinum
BoNT/E
-
Clostridium botulinum
botulinum neurotoxin type A
-
Clostridium botulinum
botulinum neurotoxin type E
-
Clostridium botulinum