Literature summary for 3.4.24.69 extracted from

Schiavo, G.; Rossetto, O.; Santucci, A.; DasGupta, B.R.; Montecucco, C.
Botulinum neurotoxins are zinc proteins (1992), J. Biol. Chem., 267, 23479-23483.

Search for more literature for 3.4.24.69

Inhibitors

Inhibitors	Comment	Organism	Structure
1,10-phenanthroline	-	Clostridium botulinum
dipicolinic acid	-	Clostridium botulinum
EDTA	r, Zn2+ restores	Clostridium botulinum

Metals/Ions

Metals/Ions	Comment	Organism	Structure
additional information	no involvement of cobalt, copper, iron, manganese or nickel, atomic absorption spectroscopy	Clostridium botulinum
Zinc	contains zinc binding motif of metalloendopeptidases His-Glu-X-X-His	Clostridium botulinum
Zinc	atom absorption spectroscopy	Clostridium botulinum
Zinc	1 atom of zinc per molecule botulinum neurotoxin (MW 150000, of serotypes A, B and E, each in 2-chain form)	Clostridium botulinum

Organism

Organism	UniProt	Comment	Textmining
Clostridium botulinum	-	serotypes BoNT/A, BoNT/B	-
Clostridium botulinum	-	BoNT/E	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	neuroparalytic activity tested by intravenous injection into Balb/c mice	Clostridium botulinum	?	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)