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Literature summary for 3.4.24.68 extracted from

  • Schiavo, G.; Benfenati, F.; Poulain, B.; Rossetto, O.; Polverino de Laureto, P.; DasGupta, B.R.; Montecucco, C.
    Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin (1992), Nature, 359, 832-835.
    View publication on PubMed
Search for more literature for 3.4.24.68

Inhibitors

Inhibitors Comment Organism Structure
Ala-Ser-Gln-Phe-Glu-Thr-Ser synthetic peptide containing cleavage site of synaptobrevin, inhibits toxin action on buccal ganglion of Aplysia californica Clostridium tetani
captopril
-
 Clostridium tetani
EDTA
-
 Clostridium tetani
Gln-Phe-Glu-Thr synthetic peptide containing cleavage site of synaptobrevin, inhibits toxin action on buccal ganglion of Aplysia californica Clostridium tetani

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc zinc-dependent endoproteinase Clostridium tetani

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
synaptobrevin + H2O Clostridium tetani enzyme disables neuroexocytosis apparatus, acts at spinal inhibitory interneurons, blocking release of various neurotransmitters to produce spastic paralysis, clostridial neurotoxins are described as the most toxic substances known ?
-
 ?
synaptobrevin + H2O Clostridium tetani neurotoxin blocks neurotransmitter release in Aplysia neurons ?
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridium tetani
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information catalytic activity requires reduction of the single interchain disulfide bond of the neurotoxin Clostridium tetani ?
-
 ?
additional information no substrates are rat or chicken Clostridium tetani ?
-
 ?
Synaptobrevin + H2O i.e. VAMP, neuronal vesicle-associated membrane protein, MW 19000, with 2 isoforms in human, chicken, in rat brain: synaptobrevin/VAMP-1 and synaptobrevin/VAMP-2, cleaves at Gln76-Phe77, the same site as botulin neurotoxin B Clostridium tetani Hydrolyzed synaptobrevin
-
 ?
synaptobrevin + H2O enzyme disables neuroexocytosis apparatus, acts at spinal inhibitory interneurons, blocking release of various neurotransmitters to produce spastic paralysis, clostridial neurotoxins are described as the most toxic substances known Clostridium tetani ?
-
 ?
synaptobrevin + H2O neurotoxin blocks neurotransmitter release in Aplysia neurons Clostridium tetani ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Clostridium tetani