Literature summary for 3.4.24.68 extracted from

Eisel, U.; Jarusch, W.; Goretzki, K.; Henschen, A.; Engels, J.; Weller, U.; Hudel, M.; Habermann, E.; Niemann, H.
Tetanus toxin: primary structure, expression in E. coli, and homology with botulinum toxins (1986), EMBO J., 5, 2495-2502.

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Cloned(Commentary)

Cloned (Comment)	Organism
Clostridium tetani	Clostridium tetani
expressed in Escherichia coli JM101 using three different plasmid vectors	Clostridium tetani

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
additional information	-	amino acid sequence homologies between tetanus toxin TeNT and botulinum toxins BoNT/A, B and E	Clostridium tetani

Organism

Organism	UniProt	Comment	Textmining
Clostridium tetani	-	E 88 (non-sporulating)	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Synaptobrevin + H2O	-	Clostridium tetani	Hydrolyzed synaptobrevin	-	?

Subunits

Subunits	Comment	Organism
More	the enzyme consists of a heavy (H) chain and a light (L) chain	Clostridium tetani
More	MW 52288 (L-chain) and MW 98300 (H-chain), calculated from amino acid sequence	Clostridium tetani

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Release 2023.1 (January 2023)