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Literature summary for 3.4.24.65 extracted from

  • Kaner, R.J.; Santiago, F.; Crystal, R.G.
    Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1(+) smokers with early emphysema (2009), J. Leukoc. Biol., 86, 913-922.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.65

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-
extracellular matrix
-
 Homo sapiens 31012
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
22000
-
 x * 22000, active MMP-12 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens a key structural component of the lung extracellular matrix ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification MMP-12 is activated from a pro-MMP-12 form Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelial lining fluid
-
 Homo sapiens
-
lung increased expression of alveolar mucosa macrophage MMP-12 in HIV-healthy smokers compared to HIV1- healthy nonsmokers. MMP-12 expression is further significantly increased in HIV1- smokers with early emphysema in comparison with both HIV1- healthy nonsmokers and HIV1- healthy smokers. Expression of alveolar mucosa MMP-12 is further increased in HIV1+ smokers with early emphysema over and above the increase in HIV1- smokers with early emphysema Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
 Homo sapiens ?
-
 ?
Elastin + H2O a key structural component of the lung extracellular matrix Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 22000, active MMP-12 Homo sapiens

Synonyms

Synonyms Comment Organism
macrophage matrix metalloproteinase
-
 Homo sapiens
MMP-12
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction degradation of elastin is central to the pathogenesis of emphysema Homo sapiens