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Literature summary for 3.4.24.64 extracted from

  • Rudhe, C.; Clifton, R.; Chew, O.; Zemam, K.; Richter, S.; Lamppa, G.; Whelan, J.; Glaser, E.
    Processing of the dual targeted precursor protein of glutathione reductase in mitochondria and chloroplasts (2004), J. Mol. Biol., 343, 639-647.
    View publication on PubMed
Search for more literature for 3.4.24.64

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Solanum tuberosum 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pea glutathione reductase + H2O Solanum tuberosum signal peptide is cleaved off by the mitochondrial processing peptidase. Removal of 30 N-terminal amino acid residues of the signal peptide (GRD1–30) greatly stimulates processing activity. Constructs with a deletion of an additional ten amino acid residues (GRD1–40) and deletion of 22 amino acid residues in the middle of the GR signal sequence (GRD30–52) are not celeaved by MPP. Mutations within two amino acid residues on either side of the processing site have inhibitory effect on processing by MPP with a nearly complete inhibition for mutations at position K1. Mutation of positively charged residues in the C-terminal half of the GR targeting peptide inhibit processing by MPP ?
-
 ?

Organism

Organism UniProt Comment Textmining
Solanum tuberosum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pea glutathione reductase + H2O
-
 Solanum tuberosum ?
-
 ?
pea glutathione reductase + H2O signal peptide is cleaved off by the mitochondrial processing peptidase. Removal of 30 N-terminal amino acid residues of the signal peptide (GRD1–30) greatly stimulates processing activity. Constructs with a deletion of an additional ten amino acid residues (GRD1–40) and deletion of 22 amino acid residues in the middle of the GR signal sequence (GRD30–52) are not celeaved by MPP. Mutations within two amino acid residues on either side of the processing site have inhibitory effect on processing by MPP with a nearly complete inhibition for mutations at position K1. Mutation of positively charged residues in the C-terminal half of the GR targeting peptide inhibit processing by MPP Solanum tuberosum ?
-
 ?

Synonyms

Synonyms Comment Organism
MPP
-
 Solanum tuberosum