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Literature summary for 3.4.24.64 extracted from

  • Arretz, M.; Schneider, H.; Guiard, B.; Brunner, M.; Neupert, W.
    Characterization of the mitochondrial processing peptidase of Neurospora crassa (1994), J. Biol. Chem., 269, 4959-4967.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Neurospora crassa
Neurospora crassa (alpha-MPP) Neurospora crassa

General Stability

General Stability Organism
Stable to 0.3-0.7 M urea Neurospora crassa

Inhibitors

Inhibitors Comment Organism Structure
additional information pb2(1-20) Neurospora crassa
Peptide pb2(15-34) derived from prepeptide of cytochrome b2 peptide pb2(1-31) Neurospora crassa
Prepeptide pb2(1-31) derived from cytochrome b2 presequence; kinetics Neurospora crassa
Prepeptide pc1(1-36) derived from cytochrome c1 presequence Neurospora crassa
Prepeptide pF1beta(1-32) derived from beta-subunit of F1-ATPase presequence Neurospora crassa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane beta-MPP, identical with core I protein of ubiquinol cytochrome c reductase complex Neurospora crassa 16020
-
mitochondrion beta-MPP: membrane-associated Neurospora crassa 5739
-
soluble
-
Neurospora crassa
-
-

Organism

Organism UniProt Comment Textmining
Neurospora crassa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant alpha-MPP and native beta-MPP Neurospora crassa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Chimeric preproteins derived from precursor of cytochrome b2 fused to dehydrofolate reductase + H2O e.g. pb2delta19(167)-DHFR, cleavage site: Arg30-Xaa31-+-Xaa32, the term -+- depicts the point of cleavage Neurospora crassa Pb2(1-31) + ib2delta19(167)-DHFR processed protein no further cleavage ?
additional information processing activity is optimal at a 1:1 molar ratio of alpha- and beta-MPP Neurospora crassa ?
-
?
Precytochrome b2-mouse dehydrofolate reductase fusion protein + H2O i.e. artificial fusion protein containing 22 amino acid presequence of cytochrome oxidase subunit IV fused to mouse dehydrofolate reductase, substitution of Arg2 or Tyr1 of matrix targeting sequence of cytochrome b2 prevents processing Neurospora crassa 31-aminoacid presequence + cytochrome b2-mouse dehydrofolate reductase protein
-
?

Subunits

Subunits Comment Organism
More processing activity is optimal at a 1:1 molar ratio of alpha- and beta-MPP Neurospora crassa
More subunits do not form a stable complex Neurospora crassa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Neurospora crassa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.7
-
-
Neurospora crassa

pH Range

pH Minimum pH Maximum Comment Organism
6.3 8.5 about half-maximal activity at pH 6.3 and about 90% of maximal activity at pH 8.5 Neurospora crassa