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Literature summary for 3.4.24.64 extracted from

  • Kleiber, J.; Kalousek, F.; Swaroop, M.; Rosenberg, L.E.
    The general mitochondrial matrix processing protease from rat liver: structural characterization of the catalytic subunit (1990), Proc. Natl. Acad. Sci. USA, 87, 7978-7982.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.64

Cloned(Commentary)

Cloned (Comment) Organism
rat (MPP1 polypeptide) Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
EDTA excess Mn2+ restores Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-
soluble
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ requirement Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
 1 * 52000 + 1 * 55000, SDS-PAGE Rattus norvegicus
55000
-
 1 * 52000 + 1 * 55000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus removes amino-terminal matrix-targeting sequences from imported mitochondrial precursor proteins during or after translocation across mitochondrial membranes ?
-
 ?
additional information Rattus norvegicus polypeptides destined to be imported from cytosol into mitochondrial matrix or inner mitochondrial membrane, critical step in the import of nuclear encoded precursor proteins into mitochondria ?
-
 ?

Organism

Organism UniProt Comment Textmining
More
-
 homology between rat, yeast and Neurospora enzymes
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
2 components, a catalytically active MW 55000 and a MW 52000 subunit in a 1:1 ratio Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information removes amino-terminal matrix-targeting sequences from imported mitochondrial precursor proteins during or after translocation across mitochondrial membranes Rattus norvegicus ?
-
 ?
additional information polypeptides destined to be imported from cytosol into mitochondrial matrix or inner mitochondrial membrane, critical step in the import of nuclear encoded precursor proteins into mitochondria Rattus norvegicus ?
-
 ?
MPPI precursor + H2O MPPI presumably takes part in its own precursor activation Rattus norvegicus MPPI
-
 ?

Subunits

Subunits Comment Organism
dimer 1 * 52000 + 1 * 55000, SDS-PAGE Rattus norvegicus