KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Michaelis-Menten enzyme kinetics, overview. Meprin B-mediated cleavage of PKA C? occurs at a rate consistent with that of other physiologically relevant meprin substrates | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
brush border membrane | - |
Mus musculus | 31526 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein kinase A + H2O | Mus musculus | the enzyme cleaves at defined sites, isoform-specific interactions between the catalytic subunit of PKA (PKA C) and meprins, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q61847 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | the enzyme is abundantly expressed in the brush-border membranes of kidney proximal tubules | Mus musculus | - |
renal tubule | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein kinase A + H2O | the enzyme cleaves at defined sites, isoform-specific interactions between the catalytic subunit of PKA (PKA C) and meprins, overview | Mus musculus | ? | - |
? | |
protein kinase A catalytic subunit Calpha + H2O | the enzyme cleaves at defined sites, cytosolic-enriched kidney proteins from meprin alphabeta double knockout mice, and purified forms of recombinant mouse PKA Calpha, Cbeta1, and Cbeta2, are incubated with activated forms of either homomeric meprinA, EC 3.4.24.18, or meprin B, product analysis by mass spectrometry, overview. Meprin B cleaves all three PKA C isoforms | Mus musculus | ? | - |
? | |
protein kinase A catalytic subunit Cbeta1 + H2O | the enzyme cleaves at defined sites, cytosolic-enriched kidney proteins from meprin alphabeta double knockout mice, and purified forms of recombinant mouse PKA Calpha, Cbeta1, and Cbeta2, are incubated with activated forms of either homomeric meprinA, EC 3.4.24.18, or meprin B, product overview. Meprin B cleaves all three PKA C isoforms | Mus musculus | ? | - |
? | |
protein kinase A catalytic subunit Cbeta2 + H2O | the enzyme cleaves at defined sites, cytosolic-enriched kidney proteins from meprin alphabeta double knockout mice, and purified forms of recombinant mouse PKA Calpha, Cbeta1, and Cbeta2, are incubated with activated forms of either homomeric meprinA, EC 3.4.24.18, or meprin B, product overview. Meprin B cleaves all three PKA C isoforms | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
meprin metalloprotease | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | meprins may impact kidney injury, in part, via modulation of protein kinase A signaling pathways, meprins are implicated in ischemia-reperfusion-induced renal injury and diabetic nephropathy. Meprin cleavage decreases the kinase activity of protein kinase A subunits Calpha, Cbeta1, and Cbeta2 | Mus musculus |