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Literature summary for 3.4.24.63 extracted from

  • Schuette, A.; Lottaz, D.; Sterchi, E.E.; Stoecker, W.; Becker-Pauly, C.
    Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio (2007), Biol. Chem., 388, 523-531.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
4 genes encoding alpha and beta subunits of the enzyme are located on chromosome 20, DNA and amino acid sequence determination and anaylsis, phylogenetic tree, sequence comparisons, overview Danio rerio

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a zinc metalloprotease with the zinc-binding motif HExxHxxGxxHE(or M) Danio rerio

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
73000
-
x * 73000, SDS-PAGE Danio rerio

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-
Danio rerio F1QRQ5 meprin alpha2 subunit
-
Danio rerio Q5RHM1 meprin alpha1 subunit
-
Danio rerio Q5RKM1 meprin alpha1 subunit
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Danio rerio

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Danio rerio
-
epidermis
-
Danio rerio
-
epithelium
-
Danio rerio
-
intestine
-
Danio rerio
-
kidney
-
Danio rerio
-
leukocyte intestinal Danio rerio
-
liver
-
Danio rerio
-
lung
-
Danio rerio
-
pancreas
-
Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information residues of the alpha1 subunit involved in the active site are Asp61 and Arg150, catalytic domain structure, overview Danio rerio ?
-
?
additional information residues of the alpha2 subunit involved in the active site are Glu80 and Lys122, catalytic domain structure, overview Danio rerio ?
-
?
additional information the residue of the beta subunit involved in the active site is Lys123, catalytic domain structure, overview Danio rerio ?
-
?

Subunits

Subunits Comment Organism
? x * 73000, SDS-PAGE Danio rerio
More all three meprin subunits identified in zebrafish contain the typical astacin domain, the Met-turn SxMHY, and the four cysteine residues that form two disulfide bonds Danio rerio

Synonyms

Synonyms Comment Organism
More the enzyme is a member of the astacin family of metalloproteases Danio rerio