Cloned (Comment) | Organism |
---|---|
4 genes encoding alpha and beta subunits of the enzyme are located on chromosome 20, DNA and amino acid sequence determination and anaylsis, phylogenetic tree, sequence comparisons, overview | Danio rerio |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | a zinc metalloprotease with the zinc-binding motif HExxHxxGxxHE(or M) | Danio rerio |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
73000 | - |
x * 73000, SDS-PAGE | Danio rerio |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | - |
- |
- |
Danio rerio | F1QRQ5 | meprin alpha2 subunit | - |
Danio rerio | Q5RHM1 | meprin alpha1 subunit | - |
Danio rerio | Q5RKM1 | meprin alpha1 subunit | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Danio rerio |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Danio rerio | - |
epidermis | - |
Danio rerio | - |
epithelium | - |
Danio rerio | - |
intestine | - |
Danio rerio | - |
kidney | - |
Danio rerio | - |
leukocyte | intestinal | Danio rerio | - |
liver | - |
Danio rerio | - |
lung | - |
Danio rerio | - |
pancreas | - |
Danio rerio | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | residues of the alpha1 subunit involved in the active site are Asp61 and Arg150, catalytic domain structure, overview | Danio rerio | ? | - |
? | |
additional information | residues of the alpha2 subunit involved in the active site are Glu80 and Lys122, catalytic domain structure, overview | Danio rerio | ? | - |
? | |
additional information | the residue of the beta subunit involved in the active site is Lys123, catalytic domain structure, overview | Danio rerio | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 73000, SDS-PAGE | Danio rerio |
More | all three meprin subunits identified in zebrafish contain the typical astacin domain, the Met-turn SxMHY, and the four cysteine residues that form two disulfide bonds | Danio rerio |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme is a member of the astacin family of metalloproteases | Danio rerio |