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Literature summary for 3.4.24.63 extracted from

  • Bertenshaw, G.P.; Turk, B.E.; Hubbard, S.J.; Matters, G.L.; Bylander, J.E.; Crisman, J.M.; Cantley, L.C.; Bond, J.S.
    Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity (2001), J. Biol. Chem., 276, 13248-13255.
    View publication on PubMed
Search for more literature for 3.4.24.63

Activating Compound

Activating Compound Comment Organism Structure
Trypsin
-
 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
actinonin
-
 Mus musculus
Pro-Leu-Gly-hydroxamate
-
 Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0071
-
 gastrin pH 7.5, 37°C Mus musculus
0.0481
-
 gastri-releasing peptide-(14-27) pH 7.5, 37°C Mus musculus
0.1
-
 orcokinin pH 7.5, 37°C Mus musculus
0.211
-
 sCCK8NH2 pH 7.5, 37°C Mus musculus
0.22
-
 glucagon pH 7.5, 37°C Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Mus musculus 9986
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 mouse strain, ICR and C3H/He
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-MSH + H2O
-
 Mus musculus ?
-
 ?
Boc-CCK8NH2 + H2O peptide of the gastrointestinal tract Mus musculus N-tert-butyloxycarbonyl-L-Asp-L-Tyr-L-Met-Gly-L-Trp-L-Met + L-Asp-L-Phe
-
 ?
CCK4 + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
CCK5 + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
CCK6 + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
CCK7 + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
CCK8 + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
CCK8NH2 + H2O peptide of the gastrointestinal tract Mus musculus L-Asp-L-Tyr-L-Met-Gly-L-Trp-L-Met + L-Asp-L-Phe
-
 ?
cerulein + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
collagen I + H2O
-
 Mus musculus ?
-
 ?
Collagen IV + H2O
-
 Mus musculus ?
-
 ?
Fibronectin + H2O
-
 Mus musculus ?
-
 ?
gastri-releasing peptide-(14-27) + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
gastrin + H2O
-
 Mus musculus ?
-
 ?
gastrin 17 + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
Gelatin + H2O
-
 Mus musculus ?
-
 ?
Glucagon + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
Laminin + H2O
-
 Mus musculus ?
-
 ?
neuropeptide Y + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
orcokinin + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
osteopontin + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
sCCK8NH2 + H2O peptide of the gastrointestinal tract Mus musculus L-Asp-L-Tyr(SO3)-L-Met-Gly-L-Trp-L-Met + L-Asp-L-Phe
-
 ?
Secretin + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
oligomer
-
 Mus musculus

Synonyms

Synonyms Comment Organism
metalloprotease meprin B
-
 Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
12.4
-
 gastrin pH 7.5, 37°C Mus musculus
12.6
-
 gastri-releasing peptide-(14-27) pH 7.5, 37°C Mus musculus
13.9
-
 sCCK8NH2 pH 7.5, 37°C Mus musculus
15.9
-
 glucagon pH 7.5, 37°C Mus musculus
23.4
-
 orcokinin pH 7.5, 37°C Mus musculus
26.8
-
 glucagon pH 7.5, 37°C Mus musculus