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Literature summary for 3.4.24.62 extracted from

  • Brakch, N.; Boussetta, H.; Rholam, M.; Cohen, P.
    Processing endoprotease recognizes a structural feature at the cleavage site of peptide prohormones. The pro-ocytocin/neurophysin model (1989), J. Biol. Chem., 264, 15912-15916.
    View publication on PubMed
Search for more literature for 3.4.24.62

Inhibitors

Inhibitors Comment Organism Structure
Cys-Lys-Gly-Gly-Lys-Arg-Ala-Val-Lys-Cys
-
 Bos taurus
Leu-Gly-Gly-Lys-Arg-Ala-Val-Lys-Asp
-
 Bos taurus
additional information pro-oxytocin/neurophysin derived peptides (overview) Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metalloendopeptidase Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
hypophysis pituitary neurosecretory granule Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information overview Bos taurus ?
-
 ?
additional information relationship between structure and enzyme action Bos taurus ?
-
 ?
additional information specificity depends on the organization of a beta-turn-alpha-helix of nine or more residues containing the basic amino acid doublet near the centre Bos taurus ?
-
 ?
additional information No substrates are oxytocin/neurophysin Bos taurus ?
-
 ?
additional information structural requirements of the substrate peptides (pro-OT/Np-model) Bos taurus ?
-
 ?
Pro-oxytocin/neurophysin(1-20) + H2O obtained by hemisynthesis Bos taurus Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) i.e. peptide II (i.e. oxytocinGly10Lys11Arg12 and peptide III) ?
Pro-oxytocin/neurophysin(1-20) + H2O strictly selective for basic amino acid doublet Lys11-Arg12, cleavage site: Arg12-Ala13 Bos taurus Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) i.e. peptide II (i.e. oxytocinGly10Lys11Arg12 and peptide III) ?
Pro-oxytocin/neurophysin(1-20) + H2O i.e. model substrate peptide I Bos taurus Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) i.e. peptide II (i.e. oxytocinGly10Lys11Arg12 and peptide III) ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus