Literature summary for 3.4.24.61 extracted from

Kimura, Y.; Ikuta, K.; Kimura, T.; Chiba, T.; Oshima, H.; Oshima, M.; Nishi, E.; Seno, H.
Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach (2017), Sci. Rep., 7, 43052 .

Search for more literature for 3.4.24.61

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8BHG1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
stomach	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
N-Arginine dibasic convertase	-	Mus musculus
NRDc	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	metaplastic changes following gastric inflammation were suppressed by the deletion of Nrdc. The deletion of Nrdc significantly suppresses N-methyl-N-nitrosourea (MNU)-induced gastric tumorigenesis in the murine stomac	Mus musculus
metabolism	the enzyme regulates inflammation, metaplasia, and tumors in murine stomach. It promotes ectodomain shedding of the precursor forms of various growth factors and cytokines by enhancing the protease activities of a disintegrin and metalloproteinase (ADAM) proteins. The enzyme crucially regulates gastric inflammation caused by Helicobacter felis infection or forced expression of prostaglandin E2 in K19-C2mE mice	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)