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Literature summary for 3.4.24.61 extracted from

  • Kanda, K.; Komekado, H.; Sawabu, T.; Ishizu, S.; Nakanishi, Y.; Nakatsuji, M.; Akitake-Kawano, R.; Ohno, M.; Hiraoka, Y.; Kawada, M.; Kawada, K.; Sakai, Y.; Matsumoto, K.; Kunichika, M.; Kimura, T.; Seno, H.; Nishi, E.; Chiba, T.
    Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-alpha (2012), EMBO Mol. Med., 4, 396-411.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ contains zinc Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-tumour necrosis factor-alpha + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43847
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-tumour necrosis factor-alpha + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
N-Arginine dibasic convertase
-
 Homo sapiens
NRDc
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens protein expression is frequently elevated both in the serum and cancer epithelium of gastric cancer patients up

General Information

General Information Comment Organism
malfunction knockdown of enzyme expression attenuates gastric cancer cell growth in vitro Homo sapiens
physiological function nardilysin promotes gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of tumor necrosis factor-alpha Homo sapiens