Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | nardilysin can generate both N termini and C termini of CTL epitopes | Homo sapiens | ? | - |
? | |
PRAME190-198 + H2O | nardilysin produces precursors of tumor-associated protein PRAME(190-198) by producing cleavage after Lys200, Arg201 and Lys202 but does not excise precisely at the C terminus (Lys198) | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
nardilysin | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | nardilysin and thimet oligopeptidase (TOP) are required, either together or alone, for the generation of a tumor-specific CTL epitope from PRAME, an immunodominant CTL epitope from Epstein-Barr virus protein EBNA3C, and a clinically important epitope from the melanoma protein MART-1 | Homo sapiens |