Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.61 extracted from

  • Bernstein, H.G.; Stricker, R.; Lendeckel, U.; Bertram, I.; Dobrowolny, H.; Steiner, J.; Bogerts, B.; Reiser, G.
    Reduced neuronal co-localisation of nardilysin and the putative alpha-secretases ADAM10 and ADAM17 in Alzheimers disease and Down syndrome brains (2009), Age (Dordr. ), 31, 11-25.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.61

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain immunolocalisation of nardilysin. In Alzheimer's disease and in Down syndrome brains there is a decreased cellular expression of nardilysin Homo sapiens
-
brain reduced neuronal co-localisation of nardilysin and the putative alpha-secretases ADAM10 and ADAM17 in Alzheimers disease and Down syndrome brains Homo sapiens
-

Synonyms

Synonyms Comment Organism
N-Arginine dibasic convertase
-
 Homo sapiens
nardilysin
-
 Homo sapiens
NRDc
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function nardilysin is involved in degradation of neuropeptides and limited intracellular proteolysis. It might play a role in human brain pathology of in Alzheimer's disease and in Down syndrome that nardilysin enhances the activity of alpha-secretases ADAM10 and ADAM17. Alzheimer's disease and in Down syndrome brains show decreased cellular expression of all three antigens, and a reduction in the number of those neurons that co-express nardilysin with ADAM10 or with ADAM17 Homo sapiens