Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | cellular localization in adult and developing brain | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | metalloendopeptidase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme interacts with the brain-specific protein p42IP4/centaurin-alpha1, the interactionis regulated by phosphatidylinositol 3,4,5-triphosphate and inositol-1,3,4,5-tetrakisphophate, nardilysin might play a role in brain development, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amygdala | neuronal cells | Homo sapiens | - |
brain | neuronal cells, wide distribution in brain | Homo sapiens | - |
brain stem | nuclei, neuronal cells | Homo sapiens | - |
cerebellum | Purkinje neurons and dendrites | Homo sapiens | - |
hypothalamus | neuronal cells | Homo sapiens | - |
neocortex | neuronal cells | Homo sapiens | - |
neuron | in cortical neurons the enzyme is partially co-localized with parvalbumin, but not with calretinin | Homo sapiens | - |
pituitary gland | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-neoendorphin + H2O | - |
Homo sapiens | ? | - |
? | |
dynorphin A + H2O | - |
Homo sapiens | ? | - |
? | |
Glucagon + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | the enzyme interacts with the brain-specific protein p42IP4/centaurin-alpha1, the interactionis regulated by phosphatidylinositol 3,4,5-triphosphate and inositol-1,3,4,5-tetrakisphophate, nardilysin might play a role in brain development, overview | Homo sapiens | ? | - |
? | |
additional information | the metalloendopeptidase cleaves N-terminal Arg or Lys residues of peptides | Homo sapiens | ? | - |
? | |
somatostatin-28 + H2O | - |
Homo sapiens | ? | - |
? |