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Literature summary for 3.4.24.59 extracted from

  • Voegtle, F.N.; Prinz, C.; Kellermann, J.; Lottspeich, F.; Pfanner, N.; Meisinger, C.
    Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization (2011), Mol. Biol. Cell, 22, 2135-2143.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ygr031w/Imo32 + H2O Ygr031w/Imo32 encodes an Oct1 substrate protein with an unusual sequence motif Saccharomyces cerevisiae ?
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?

Synonyms

Synonyms Comment Organism
OCT1
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Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function the stability of intermediate and mature forms of Oct1 substrate proteins in organello and in vivo is compared. Oct1 cleavage increases the half-life of its substrate proteins, most likely by re-moving destabilizing amino acids at the intermediate's N-terminus. Oct1 converts unstable precursor intermediates generated by mitochondrial processing peptidase (MPP) into stable mature proteins. Oct1 acts as a quality control system for MPP-processed preproteins Saccharomyces cerevisiae