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Literature summary for 3.4.24.59 extracted from

  • Lee, S.F.; Srinivasan, B.; Sephton, C.F.; Dries, D.R.; Wang, B.; Yu, C.; Wang, Y.; Dewey, C.M.; Shah, S.; Jiang, J.; Yu, G.
    Gamma-secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate peptidase (2011), J. Biol. Chem., 286, 27447-27453.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.59

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Purification (Commentary)

Purification (Comment) Organism
recombinant MIPEP protein is purified from baculovirus-infected Sf9 cells Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Notch receptor + H2O Notch is proteolysed at the S5 site which is 8 amino acids downstream of the S3 site, generating a DELTA NICD (Notch intracellular domain) fragment Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
MIPEP
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 Homo sapiens
mitochondrial intermediate peptidase
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 Homo sapiens

General Information

General Information Comment Organism
malfunction cleavage of Notch recptor at the S5 site is abolished in MIEP knockout cells Homo sapiens
physiological function Notch function can be modulated by MIPEP-mediated cleavage. Results show that S5 site proteolysis represents a novel regulatory component of Notch signaling Homo sapiens