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Literature summary for 3.4.24.59 extracted from
- Rat liver mitochondrial intermediate peptidase (MIP): purification and initial characterization (1992), EMBO J., 11, 2803-2809.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amastatin | - |
Rattus norvegicus |  |
| Co2+ | 1 mM | Rattus norvegicus | |
| EDTA | - |
Rattus norvegicus | |
| Fe2+ | 1 mM | Rattus norvegicus | |
| leupeptin | - |
Rattus norvegicus | |
| additional information | no inhibition by NaCl or KCl at concentrations up to 200 mM | Rattus norvegicus | |
| NEM | - |
Rattus norvegicus | |
| pepstatin | - |
Rattus norvegicus | |
| Zn2+ | 1 mM | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial matrix | - |
Rattus norvegicus | 5759 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 1 mM, stimulates 2.2fold | Rattus norvegicus | |
| Mg2+ | 1 mM, stimulates 4.8fold | Rattus norvegicus | |
| Mn2+ | 1 mM, stimulates 4.5fold | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 75000 | - |
rat, gel filtration | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, stable for at least 6 months | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Mitochondrial intermediate proteins + H2O | - |
Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 75000, SDS-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.6 | 8.9 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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