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Literature summary for 3.4.24.58 extracted from
- Russellysin (2004), Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 683-684.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | russellysin is able to inhibit platelet aggregation but the RGD sequence is replaced by Arg-Asp-Glu in the corresponding region | Protobothrops mucrosquamatus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | - |
Protobothrops mucrosquamatus |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | essential for proteolytic activity | Protobothrops mucrosquamatus | |
| Zn2+ | essential for proteolytic activity | Protobothrops mucrosquamatus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 18000 | - |
light chain | Protobothrops mucrosquamatus |
| 21000 | - |
light chain | Protobothrops mucrosquamatus |
| 59000 | - |
heavy chain, consists of metalloproteinase, disintegrin and cysteine-rich domains | Protobothrops mucrosquamatus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Protobothrops mucrosquamatus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Protobothrops mucrosquamatus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Protobothrops mucrosquamatus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| coagulation factor IX + H2O | cleavage at the Arg-Xaa bond | Protobothrops mucrosquamatus | ? | - |
? | |
| coagulation factor X + H2O | cleavage at the Arg-Ile bond | Protobothrops mucrosquamatus | ? | - |
? | |
| additional information | no action on the B chain of insulin | Protobothrops mucrosquamatus | ? | - |
? | |
| o-aminobenzoyl-Gly-Phe-Arg-Leu-Leu-2,4-dinitroanilinoethylamide + H2O | - |
Protobothrops mucrosquamatus | ? | - |
? | |
| protein C + H2O | cleavage at the Arg-Xaa bond | Protobothrops mucrosquamatus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Russell`s viper venom coagulation factor X-activating enzyme | - |
Protobothrops mucrosquamatus |
| RVV-X | - |
Protobothrops mucrosquamatus |
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