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Literature summary for 3.4.24.56 extracted from

  • Song, E.S.; Jang, H.; Guo, H.F.; Juliano, M.A.; Juliano, L.; Morris, A.J.; Galperin, E.; Rodgers, D.W.; Hersh, L.B.
    Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes (2017), Proc. Natl. Acad. Sci. USA, 114, E2826-E2835.
    View publication on PubMed
Search for more literature for 3.4.24.56

Activating Compound

Activating Compound Comment Organism Structure
1-diphosphoinositol pentakisphosphate activates, maximal 79.7fold activation Rattus norvegicus
5-diphosphoinositol pentakisphosphate activates, maximal 94.7fold activation Rattus norvegicus
myoinositol 1,2,3,4,5,6-hexakisphosphate i.e. phytic acid, maximal 72fold activation Rattus norvegicus
myoinositol 1,2-bisphosphate activates, maximal 3.1fold activation Rattus norvegicus
myoinositol 1,3,4,5,6-pentakisphosphate activates, maximal 83.3fold activation Rattus norvegicus
myoinositol 1,3,4,5-tetrakisphosphate activates, maximal 58.6fold activation Rattus norvegicus
myoinositol 1,3,5-trisphosphate activates, maximal 12.9fold activation Rattus norvegicus
myoinositol 1,3-bisphosphate activates, maximal 6.1fold activation Rattus norvegicus
myoinositol 1,4,5-trisphosphate activates, maximal 30.6fold activation Rattus norvegicus
myoinositol 3-phosphate activates, maximal 6.2fold activation Rattus norvegicus
myoinositol 4,5-bisphosphate activates, maximal 13.8fold activation Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
K898A/K899A/S901A variant with mutations in the polyanion-binding site shows reduced activation by myoinositol 1,4,5-trisphosphate and phytic acid Rattus norvegicus
Y609F activation by myoinositol 1,4,5-trisphosphate and phytic acid is decreased in the mutant enzyme Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0111
-
 Abz-Gly-Gly-Leu-Arg-Lys-His-Gly-Gln-EDDnp 37°C, pH 7.4, without activator Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome binding to phosphatdidylinositol phosphates facilitates its localization to endosomes Rattus norvegicus 5768
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P35559
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-Gly-Gly-Leu-Arg-Lys-His-Gly-Gln-EDDnp + H2O
-
 Rattus norvegicus ?
-
 ?
amyloid beta-peptide(1-40) + H2O
-
 Rattus norvegicus ?
-
 ?
angiotensin + H2O
-
 Rattus norvegicus ?
-
 ?
beta-endorphin + H2O
-
 Rattus norvegicus ?
-
 ?
bradykinin + H2O
-
 Rattus norvegicus ?
-
 ?
dynorphin B9 + H2O
-
 Rattus norvegicus ?
-
 ?
Glucagon + H2O
-
 Rattus norvegicus ?
-
 ?
insulin + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
IDE
-
 Rattus norvegicus
Insulin-degrading enzyme
-
 Rattus norvegicus