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Literature summary for 3.4.24.56 extracted from

  • Suire, C.N.; Nainar, S.; Fazio, M.; Kreutzer, A.G.; Paymozd-Yazdi, T.; Topper, C.L.; Thompson, C.R.; Leissring, M.A.
    Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display (2018), PLoS ONE, 13, e0193101 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.56

Inhibitors

Inhibitors Comment Organism Structure
ACSWWSIHLCG
-
 Mus musculus
QSLPWCYPHCVT
-
 Mus musculus
QSLPWCYPHCVT-NH2 the substrate contains two cysteine residues, which are predicted to form a disulfide bond that cyclizes the peptide, together with 2 proline residues. By virtue of its potency, stability, specificity for insulin-degrading enzyme, low cost of synthesis, and demonstrated ability to potentiate insulin-induced processes involved in wound healing and skin health, the inhibitor holds significant therapeutic and cosmetic potential for topical applications Mus musculus
VHWDFRQW-NH2
-
 Mus musculus
VHWDFRQWWQPS
-
 Mus musculus
VHWDFRQWWQPS-NH2
-
 Mus musculus
WSPISGKFFQRF
-
 Mus musculus
WSPISGKFFQRF-NH2
-
 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-metalloendopeptidase Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JHR7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin fibroblast
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
IDE
-
 Mus musculus
Insulin-degrading enzyme
-
 Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0008
-
 VHWDFRQWWQPS pH and temperature not specified in the publication, substrate: insulin Mus musculus
0.0013
-
 VHWDFRQWWQPS-NH2 pH and temperature not specified in the publication, substrate: insulin Mus musculus
0.0015
-
 WSPISGKFFQRF pH and temperature not specified in the publication, substrate: insulin Mus musculus
0.0026
-
 WSPISGKFFQRF-NH2 pH and temperature not specified in the publication, substrate: insulin Mus musculus
0.0037
-
 ACSWWSIHLCG pH and temperature not specified in the publication, substrate: insulin Mus musculus
0.0039
-
 QSLPWCYPHCVT pH and temperature not specified in the publication, substrate: insulin Mus musculus
0.0041
-
 QSLPWCYPHCVT-NH2 pH and temperature not specified in the publication, substrate: insulin Mus musculus
0.007
-
 VHWDFRQW-NH2 pH and temperature not specified in the publication, substrate: insulin Mus musculus