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Literature summary for 3.4.24.56 extracted from

  • Yang, D.; Qin, W.; Shi, X.; Zhu, B.; Xie, M.; Zhao, H.; Teng, B.; Wu, Y.; Zhao, R.; Yin, F.; Ren, P.; Liu, L.; Li, Z.
    Stabilized beta-hairpin peptide inhibits insulin degrading enzyme (2018), J. Med. Chem., 61, 8174-8185 .
    View publication on PubMed
Search for more literature for 3.4.24.56

Application

Application Comment Organism
medicine peptide inhibitors cand function as potentially meaningful candidates for the development of type-2 diabetes therapeutics Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Ac-EWRFCGdPPECLYLVCG-NH2(Cys5-Cys10 disulfide)
-
 Mus musculus
Ac-EWRFCGGGdPPECLYLVCG-NH2(Cys5-Cys12-disulfide)
-
 Mus musculus
EALYLVCG-NH2
-
 Mus musculus
EALYLVCGdPPFRWE-NH2
-
 Mus musculus
EWRF-cyclo(DGdPPEDap)LYLVCG-NH2
-
 Mus musculus
EWRF-cyclo(DGGGdPPEDap)LYLVCG-NH2
-
 Mus musculus
EWRFdPPEALY-NH2
-
 Mus musculus
EWRFdPPEALYLV-NH2
-
 Mus musculus
EWRFGGEALYLVCG-NH2
-
 Mus musculus
RFdPPEALY-NH2
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin + H2O Mus musculus the enzyme plays a critical role in both the proteolytic degradation and inactivation of insulin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JHR7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin + H2O
-
 Mus musculus ?
-
 ?
insulin + H2O the enzyme plays a critical role in both the proteolytic degradation and inactivation of insulin Mus musculus ?
-
 ?
[(7-methoxycoumarin-4-yl)acetyl]-RPPGFSAFK(Dnp)-OH + H2O
-
 Mus musculus [(7-methoxycoumarin-4-yl)acetyl]-RPPGF + SAFK(Dnp)-OH
-
 ir

Synonyms

Synonyms Comment Organism
insulin degrading enzyme
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000022
-
 pH 7.5, 23°C Mus musculus EWRF-cyclo(DGdPPEDap)LYLVCG-NH2
0.000044
-
 pH 7.5, 23°C Mus musculus EWRF-cyclo(DGGGdPPEDap)LYLVCG-NH2
0.00006
-
 pH 7.5, 23°C Mus musculus Ac-EWRFCGdPPECLYLVCG-NH2(Cys5-Cys10 disulfide)
0.000077
-
 pH 7.5, 23°C Mus musculus Ac-EWRFCGGGdPPECLYLVCG-NH2(Cys5-Cys12-disulfide)
0.000086
-
 pH 7.5, 23°C Mus musculus EWRFdPPEALYLV-NH2
0.00017
-
 pH 7.5, 23°C Mus musculus EALYLVCGdPPFRWE-NH2
0.00023
-
 pH 7.5, 23°C Mus musculus EALYLVCG-NH2
0.0003
-
 pH 7.5, 23°C Mus musculus EWRFGGEALYLVCG-NH2
0.000601
-
 pH 7.5, 23°C Mus musculus EWRFdPPEALY-NH2

General Information

General Information Comment Organism
physiological function the enzyme plays a critical role in both the proteolytic degradation and inactivation of insulin Mus musculus