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Literature summary for 3.4.24.56 extracted from

  • Tundo, G.R.; Di Muzio, E.; Ciaccio, C.; Sbardella, D.; Di Pierro, D.; Polticelli, F.; Coletta, M.; Marini, S.
    Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin (2016), FEBS J., 283, 3755-3770 .
    View publication on PubMed
Search for more literature for 3.4.24.56

Activating Compound

Activating Compound Comment Organism Structure
Somatostatin enhances the proteolytic processing of a synthetic beta-amyloid-peptide. In addition to being a substrate, somatostatin is also able to bind to two additional exosites, which play different roles according to the size of the substrate and its binding mode to the catalytic cleft of the enzyme. One exosite, which displays high affinity for somatostatin, regulates only the interaction of insulin-degrading-enzyme with larger substrates (such as insulin and beta-amyloid1-40) in a differing fashion according to their various modes of binding to the enzyme. A second exosite, which is involved in the regulation of enzymatic processing by the enzyme of all substrates investigated (including a 10-25 amino acid long amyloid-like peptide, bradykinin and somatostatin itself), probably acts through the alteration of an open-closed equilibrium Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14735
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid (Abeta)1-40 + H2O
-
 Homo sapiens ?
-
 ?
bradykinin + H2O
-
 Homo sapiens ?
-
 ?
insulin + H2O
-
 Homo sapiens ?
-
 ?
somatostatin + H2O somatostatin in addition to being a substrate, is also able to bind to two additional exosites, which play different roles according to the size of the substrate and its binding mode to the catalytic cleft of the enzyme. One exosite, which displays high affinity for somatostatin, regulates only the interaction of insulin-degrading-enzyme with larger substrates (such as insulin and beta-amyloid1-40) in a differing fashion according to their various modes of binding to the enzyme. A second exosite, which is involved in the regulation of enzymatic processing by the enzyme of all substrates investigated (including a 10-25 amino acid long amyloid-like peptide, bradykinin and somatostatin itself), probably acts through the alteration of an open-closed equilibrium Homo sapiens ?
-
 ?