Literature summary for 3.4.24.56 extracted from

Hubin, E.; Cioffi, F.; Rozenski, J.; van Nuland, N.A.; Broersen, K.
Characterization of insulin-degrading enzyme-mediated cleavage of Abeta in distinct aggregation states (2016), Biochim. Biophys. Acta, 1860, 1281-1290 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
amyloid-beta + H2O	Homo sapiens	activity is driven by the dynamic equilibrium between Abeta monomers and higher ordered aggregates. Met35-Val36 is a cleavage site in the amyloid-beta sequence. Amyloid-beta fragments resulting from cleavage by insulin-degrading enzyme form non-toxic amorphous aggregates	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14735	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
amyloid-beta + H2O	activity is driven by the dynamic equilibrium between Abeta monomers and higher ordered aggregates. Met35-Val36 is a cleavage site in the amyloid-beta sequence. Amyloid-beta fragments resulting from cleavage by insulin-degrading enzyme form non-toxic amorphous aggregates	Homo sapiens	?	-	?
amyloid-beta + H2O	amyloid-beta monomers, either alone in solution or in dynamic equilibrium with higher aggregates, are cleaved at multiple sites by activity of insulin-degrading enzyme. Met35-Val36 is a cleavage site in the amyloid-beta sequence. Amyloid-beta fragments resulting from cleavage by insulin-degrading enzyme form non-toxic amorphous aggregates	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
IDE	-	Homo sapiens
Insulin-degrading enzyme	-	Homo sapiens

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Release 2023.1 (January 2023)