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Literature summary for 3.4.24.56 extracted from
- Resveratrol sustains insulin-degrading enzyme activity toward Abeta42 (2018), ACS Omega, 3, 13275-13282 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| resveratrol | incubation with resveratrol results in a substantial increase in Abeta42 fragmentation compared to the control, signifying that the polyphenol sustains insulin-degrading enzyme-dependent degradation of Abeta42 and its fragments | Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | therapeutic and/or preventative approaches combining resveratrol and insulin-degrading enzyme may hold promise for sporadic Alzheimer's disease | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| glutathione S-transferase-tagged human insulin-degrading enzyme in pGEX-6p-1 vector is transformed into Escherichia coli BL21-CodonPlus (DE3) competent cells | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Abeta42 + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P14735 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Abeta42 + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Insulin-degrading enzyme | - |
Homo sapiens |
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