Literature summary for 3.4.24.56 extracted from

Galagovsky, D.; Katz, M.; Acevedo, J.; Sorianello, E.; Glavic, A.; Wappner, P.
The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner (2014), Mol. Biol. Cell, 25, 916-924.

Search for more literature for 3.4.24.56

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Drosophila melanogaster	5737	-
plasma membrane	-	Drosophila melanogaster	5886	-

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	P22817	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adult	highest expression in male adults	Drosophila melanogaster	-
body wall	-	Drosophila melanogaster	-
brain	-	Drosophila melanogaster	-
fat body	highest expression	Drosophila melanogaster	-
gut	-	Drosophila melanogaster	-
imaginal disc	-	Drosophila melanogaster	-
larva	-	Drosophila melanogaster	-
pupa	-	Drosophila melanogaster	-
salivary gland	-	Drosophila melanogaster	-

Synonyms

Synonyms	Comment	Organism
IDE	-	Drosophila melanogaster
Insulin-degrading enzyme	-	Drosophila melanogaster

General Information

General Information	Comment	Organism
malfunction	loss of enzyme function favors insulin resistance, a hallmark of diabetes mellitus type II. Down-regulation of the enzyme provokes reduction of tissue growth and sensitizes developmental timing and metabolism to high-sucrose diets	Drosophila melanogaster
metabolism	the enzyme can modulate Drosophila insulin-like peptide 2 levels, thereby restricting activation of the phosphatidylinositol-3-phosphate kinase pathway and promoting activation of Drosophila forkhead box, subgroup O transcription factor	Drosophila melanogaster
physiological function	the enzyme provokes growth reduction mediated by the phosphatidylinositol-3-phosphate kinase pathway in a cell-autonomous manner	Drosophila melanogaster

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Release 2023.1 (January 2023)