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Literature summary for 3.4.24.56 extracted from
- Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's disease (2010), Neurobiol. Aging, 31, 1743-1757.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | study on cortical expression of insulysin and neprilysin in sporadic and familial Alzheimer's disease samples carrying the E280A presenilin-1 missense mutation. Insulysin is linked with aggregated amyloid beta40 isoform while neprilysin negatively correlates with amyloid angiopathy. Neprilysin, but not insulysin, is over-expressed in dystrophic neurites, both proteases are immunoreactive in activated astrocytes but not in microglia and insulysin is the only one detected in astrocytes of white matter from familial alzheimer's disease cases | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
patients with sporadic and familial Alzheimer's disease | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
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Release 2023.1 (January 2023)
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