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Literature summary for 3.4.24.56 extracted from

  • Song, E.S.; Juliano, M.A.; Juliano, L.; Fried, M.G.; Wagner, S.L.; Hersh, L.B.
    ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety (2004), J. Biol. Chem., 279, 54216-54220.
    View publication on PubMed
Search for more literature for 3.4.24.56

Activating Compound

Activating Compound Comment Organism Structure
ADP in Tris buffer, activation for substrate 2-aminobenzoyl-GGFLRKHGQ-(N-(2,4-dinitrophenyl)ethylenediamine). Activation in decreasing order: ATP, triphosphate, ADP, AMP Rattus norvegicus
AMP in Tris buffer, activation for substrate 2-aminobenzoyl-GGFLRKHGQ-(N-(2,4-dinitrophenyl)ethylenediamine). Activation in decreasing order: ATP, triphosphate, ADP, AMP Rattus norvegicus
ATP in Tris buffer, up to 20fold activation for substrate 2-aminobenzoyl-GGFLRKHGQ-(N-(2,4-dinitrophenyl)ethylenediamine), noncompetitive activator. Activation in decreasing order: ATP, triphosphate, ADP, AMP. Up to 10fold activation with substrates bradykinin, dynorphin B-9. No activation with substrates insulin or amyloid beta-protein Rattus norvegicus
Triphosphate in Tris buffer, up to 20fold activation for substrate 2-aminobenzoyl-GGFLRKHGQ-(N-(2,4-dinitrophenyl)ethylenediamine), noncompetitive activator. Activation in decreasing order: ATP, triphosphate, ADP, AMP. Up to 10fold activation with substrates bradykinin, dynorphin B-9. No activation with substrates insulin or amyloid beta-protein Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 recombinant enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminobenzoyl-GGFLRKHGQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
-
 Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
More sedimentation analysis shows that enzyme in Tris buffers mainly consists of monomers and dimers, in phosphate buffer there are monomers, dimers and tetramers. Tris buffer supplemented with 4 mM triphosphate contains enzyme as monomer and high oligomers, but without dimers Rattus norvegicus